High risk of cutaneous melanoma amongst carriers of the intercellular adhesion molecule-1 R241 allele

Marco Vinceti, Giovanni Pellacani, Bruno Casali, Carlotta Malagoli, Davide Nicoli, Enrico Farnetti, Stefania Bassissi, Margherita Bergomi, Stefania Seidenari

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We examined the relation between cutaneous melanoma risk and the intercellular adhesion molecule-1 (ICAM-1) gene single nucleotide polymorphisms G241R and K469E, as well as the circulating soluble form of ICAM-1 determined in plasma, in the population of Modena Province, northern Italy. Individuals carrying at least one R241 allele, versus those carrying the wild-type GG genotype, had a relative risk of melanoma of 4.3 (P=0.022), whereas the K469E polymorphism was unrelated to disease risk. Soluble ICAM-1 levels above 10 ng/ml directly and strongly correlated with melanoma risk. In this population, individuals carrying the R241 allele of the ICAM-1 gene appeared to show an enhanced susceptibility to cutaneous melanoma, possibly because of increased ICAM-1 expression.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalMelanoma Research
Volume16
Issue number1
DOIs
Publication statusPublished - 2006

Fingerprint

Intercellular Adhesion Molecule-1
Melanoma
Alleles
Skin
Italy
Population
Genes
Single Nucleotide Polymorphism
Genotype

Keywords

  • Case-control study
  • Epidemiology
  • Genetic polymorphism
  • Intercellular adhesion molecule-1
  • Melanoma

ASJC Scopus subject areas

  • Cancer Research
  • Dermatology

Cite this

High risk of cutaneous melanoma amongst carriers of the intercellular adhesion molecule-1 R241 allele. / Vinceti, Marco; Pellacani, Giovanni; Casali, Bruno; Malagoli, Carlotta; Nicoli, Davide; Farnetti, Enrico; Bassissi, Stefania; Bergomi, Margherita; Seidenari, Stefania.

In: Melanoma Research, Vol. 16, No. 1, 2006, p. 93-96.

Research output: Contribution to journalArticle

Vinceti, Marco ; Pellacani, Giovanni ; Casali, Bruno ; Malagoli, Carlotta ; Nicoli, Davide ; Farnetti, Enrico ; Bassissi, Stefania ; Bergomi, Margherita ; Seidenari, Stefania. / High risk of cutaneous melanoma amongst carriers of the intercellular adhesion molecule-1 R241 allele. In: Melanoma Research. 2006 ; Vol. 16, No. 1. pp. 93-96.
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AU - Farnetti, Enrico

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AU - Bergomi, Margherita

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