High-sensitive cardiac troponin T (hs-cTnT) assay as serum biomarker to predict cardiac risk in myotonic dystrophy: A case-control study

Rea Valaperta, Maddalena Gaeta, Rosanna Cardani, Fortunata Lombardi, Benedetta Rampoldi, Claudia De Siena, Francesca Mori, Barbara Fossati, Paola Gaia, Ottavia Eleonora Ferraro, Simona Villani, Sara Iachettini, Marco Piccoli, Federica Cirillo, Enrico Pusineri, Giovanni Meola, Elena Costa

Research output: Contribution to journalArticle

Abstract

Background Myotonic dystrophy (DM) is a genetic disorder caused by nucleotide repeats expansion. Sudden death represents the main cause of mortality in DM patients. Here, we investigated the relationship between serum cardiac biomarkers with clinical parameters in DM patients. Methods Case-control study included 59 DM patients and 22 healthy controls. An additional group of 62 controls with similar cardiac defects to DM were enrolled. Results NT-proBNP, hs-cTnT and CK levels were significantly increased in DM patients compared to healthy subjects (p = 0.0008, p < 0.0001, p < 0.0001). Also, hs-cTnT levels were significantly higher in DM compared to control group with cardiac defects (p = 0.0003). Positive correlation was found between hs-cTnT and hs-cTnI in both DM patients and controls (p = 0.019, p = 0.002). Independently from the age, the risk of DM disease was positively related to an increase in hs-cTnT (p = 0.03). On the contrary, the risk of DM was not related to hs-cTnI, but was evidenced a role of PR interval (p = 0.03) and CK (p = 0.08). Conclusions The levels of hs-cTnT were significantly higher in DM patients. Analysis, with anti-cTnT, shows that this increase might be linked to heart problems. This last finding suggests that hs-cTnT might represent a helpful serum biomarker to “predict” cardiac risk in DM disease.

Original languageEnglish
Pages (from-to)122-128
Number of pages7
JournalClinica Chimica Acta
Volume463
DOIs
Publication statusPublished - Dec 1 2016

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Keywords

  • Cardiac involvement
  • hs-cTnI
  • hs-cTnT
  • Myotonic dystrophy

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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