High-sensitive cardiac troponin T (hs-cTnT) assay as serum biomarker to predict cardiac risk in myotonic dystrophy

A case-control study

Rea Valaperta, Maddalena Gaeta, Rosanna Cardani, Fortunata Lombardi, Benedetta Rampoldi, Claudia De Siena, Francesca Mori, Barbara Fossati, Paola Gaia, Ottavia Eleonora Ferraro, Simona Villani, Sara Iachettini, Marco Piccoli, Federica Cirillo, Enrico Pusineri, Giovanni Meola, Elena Costa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background Myotonic dystrophy (DM) is a genetic disorder caused by nucleotide repeats expansion. Sudden death represents the main cause of mortality in DM patients. Here, we investigated the relationship between serum cardiac biomarkers with clinical parameters in DM patients. Methods Case-control study included 59 DM patients and 22 healthy controls. An additional group of 62 controls with similar cardiac defects to DM were enrolled. Results NT-proBNP, hs-cTnT and CK levels were significantly increased in DM patients compared to healthy subjects (p = 0.0008, p < 0.0001, p < 0.0001). Also, hs-cTnT levels were significantly higher in DM compared to control group with cardiac defects (p = 0.0003). Positive correlation was found between hs-cTnT and hs-cTnI in both DM patients and controls (p = 0.019, p = 0.002). Independently from the age, the risk of DM disease was positively related to an increase in hs-cTnT (p = 0.03). On the contrary, the risk of DM was not related to hs-cTnI, but was evidenced a role of PR interval (p = 0.03) and CK (p = 0.08). Conclusions The levels of hs-cTnT were significantly higher in DM patients. Analysis, with anti-cTnT, shows that this increase might be linked to heart problems. This last finding suggests that hs-cTnT might represent a helpful serum biomarker to “predict” cardiac risk in DM disease.

Original languageEnglish
Pages (from-to)122-128
Number of pages7
JournalClinica Chimica Acta
Volume463
DOIs
Publication statusPublished - Dec 1 2016

Fingerprint

Myotonic Dystrophy
Troponin T
Biomarkers
Case-Control Studies
Assays
Serum
Control Groups
Defects
Inborn Genetic Diseases
Sudden Death
Healthy Volunteers
Nucleotides
Mortality

Keywords

  • Cardiac involvement
  • hs-cTnI
  • hs-cTnT
  • Myotonic dystrophy

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

High-sensitive cardiac troponin T (hs-cTnT) assay as serum biomarker to predict cardiac risk in myotonic dystrophy : A case-control study. / Valaperta, Rea; Gaeta, Maddalena; Cardani, Rosanna; Lombardi, Fortunata; Rampoldi, Benedetta; De Siena, Claudia; Mori, Francesca; Fossati, Barbara; Gaia, Paola; Ferraro, Ottavia Eleonora; Villani, Simona; Iachettini, Sara; Piccoli, Marco; Cirillo, Federica; Pusineri, Enrico; Meola, Giovanni; Costa, Elena.

In: Clinica Chimica Acta, Vol. 463, 01.12.2016, p. 122-128.

Research output: Contribution to journalArticle

Valaperta, Rea ; Gaeta, Maddalena ; Cardani, Rosanna ; Lombardi, Fortunata ; Rampoldi, Benedetta ; De Siena, Claudia ; Mori, Francesca ; Fossati, Barbara ; Gaia, Paola ; Ferraro, Ottavia Eleonora ; Villani, Simona ; Iachettini, Sara ; Piccoli, Marco ; Cirillo, Federica ; Pusineri, Enrico ; Meola, Giovanni ; Costa, Elena. / High-sensitive cardiac troponin T (hs-cTnT) assay as serum biomarker to predict cardiac risk in myotonic dystrophy : A case-control study. In: Clinica Chimica Acta. 2016 ; Vol. 463. pp. 122-128.
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abstract = "Background Myotonic dystrophy (DM) is a genetic disorder caused by nucleotide repeats expansion. Sudden death represents the main cause of mortality in DM patients. Here, we investigated the relationship between serum cardiac biomarkers with clinical parameters in DM patients. Methods Case-control study included 59 DM patients and 22 healthy controls. An additional group of 62 controls with similar cardiac defects to DM were enrolled. Results NT-proBNP, hs-cTnT and CK levels were significantly increased in DM patients compared to healthy subjects (p = 0.0008, p < 0.0001, p < 0.0001). Also, hs-cTnT levels were significantly higher in DM compared to control group with cardiac defects (p = 0.0003). Positive correlation was found between hs-cTnT and hs-cTnI in both DM patients and controls (p = 0.019, p = 0.002). Independently from the age, the risk of DM disease was positively related to an increase in hs-cTnT (p = 0.03). On the contrary, the risk of DM was not related to hs-cTnI, but was evidenced a role of PR interval (p = 0.03) and CK (p = 0.08). Conclusions The levels of hs-cTnT were significantly higher in DM patients. Analysis, with anti-cTnT, shows that this increase might be linked to heart problems. This last finding suggests that hs-cTnT might represent a helpful serum biomarker to “predict” cardiac risk in DM disease.",
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author = "Rea Valaperta and Maddalena Gaeta and Rosanna Cardani and Fortunata Lombardi and Benedetta Rampoldi and {De Siena}, Claudia and Francesca Mori and Barbara Fossati and Paola Gaia and Ferraro, {Ottavia Eleonora} and Simona Villani and Sara Iachettini and Marco Piccoli and Federica Cirillo and Enrico Pusineri and Giovanni Meola and Elena Costa",
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AU - Valaperta, Rea

AU - Gaeta, Maddalena

AU - Cardani, Rosanna

AU - Lombardi, Fortunata

AU - Rampoldi, Benedetta

AU - De Siena, Claudia

AU - Mori, Francesca

AU - Fossati, Barbara

AU - Gaia, Paola

AU - Ferraro, Ottavia Eleonora

AU - Villani, Simona

AU - Iachettini, Sara

AU - Piccoli, Marco

AU - Cirillo, Federica

AU - Pusineri, Enrico

AU - Meola, Giovanni

AU - Costa, Elena

PY - 2016/12/1

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N2 - Background Myotonic dystrophy (DM) is a genetic disorder caused by nucleotide repeats expansion. Sudden death represents the main cause of mortality in DM patients. Here, we investigated the relationship between serum cardiac biomarkers with clinical parameters in DM patients. Methods Case-control study included 59 DM patients and 22 healthy controls. An additional group of 62 controls with similar cardiac defects to DM were enrolled. Results NT-proBNP, hs-cTnT and CK levels were significantly increased in DM patients compared to healthy subjects (p = 0.0008, p < 0.0001, p < 0.0001). Also, hs-cTnT levels were significantly higher in DM compared to control group with cardiac defects (p = 0.0003). Positive correlation was found between hs-cTnT and hs-cTnI in both DM patients and controls (p = 0.019, p = 0.002). Independently from the age, the risk of DM disease was positively related to an increase in hs-cTnT (p = 0.03). On the contrary, the risk of DM was not related to hs-cTnI, but was evidenced a role of PR interval (p = 0.03) and CK (p = 0.08). Conclusions The levels of hs-cTnT were significantly higher in DM patients. Analysis, with anti-cTnT, shows that this increase might be linked to heart problems. This last finding suggests that hs-cTnT might represent a helpful serum biomarker to “predict” cardiac risk in DM disease.

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