Abstract
An assay of high sensitivity and specificity for detection of residual malignant cells in remission bone marrow from patients with acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL) has been developed. The assay combined an immunoselection step with immunoglobulin gene rearrangement analysis by high specific-activity DNA Probes. In experimental conditions, less than one contaminating tumor cell out of 1000 bone marrow cells was detected. A bone marrow contamination was detected in morphologically negative bone marrow specimens from two intermediate-grate non-Hodgkin's lymphoma patients. This method can be of value in determining a true remission status in high-risk ALL and NHL patients.
| Original language | English |
|---|---|
| Pages (from-to) | 473-482 |
| Number of pages | 10 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 511 |
| Publication status | Published - 1987 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Bregni, M., Siena, S., Dalla-Favera, R., & Gianni, A. M. (1987). High sensitivity and specificity assay for detection of leukemia/lymphoma cells in human bone marrow. Annals of the New York Academy of Sciences, 511, 473-482.