TY - JOUR
T1 - High-sensitivity C-reactive protein is a predictive factor of adiposity in children
T2 - Results of the identification and prevention of dietary-and lifestyle-induced health effects in children and infants (IDEFICS) study
AU - Nappo, Annunziata
AU - Iacoviello, Licia
AU - Fraterman, Arno
AU - Gonzalez-Gil, Esther M.
AU - Hadjigeorgiou, Charis
AU - Marild, Staffan
AU - Molnar, Denes
AU - Moreno, Luis A.
AU - Peplies, Jenny
AU - Sioen, Isabel
AU - Veidebaum, Toomas
AU - Siani, Alfonso
AU - Russo, Paola
PY - 2013
Y1 - 2013
N2 - Background--Whereas cross-sectional studies have shown that obesity is associated with increased C-reactive protein (CRP) levels in children, little is known about the impact of low-grade inflammation on body mass changes during growth. Methods and Results--We assessed cross-sectionally and longitudinally the association of high-sensitivity (hs)-CRP levels with overweight/obesity and related cardiometabolic risk factors in the Identification and prevention of Dietary-and lifestyle-induced health Effects in Children and InfantS (IDEFICS) cohort. 16 224 children from 8 European countries (2 to 9 years) were recruited during the baseline survey (T0). After the exclusion of 7187 children because of missing hs-CRP measurements and 2421 because of drug use during the previous week, the analysis was performed on 6616 children (Boys=3347; Girls=3269; age=6.3±1.7 years). Of them, 4110 were reexamined 2 years later (T1). Anthropometric variables, blood pressure, hs-CRP, blood lipids, glucose and insulin were measured. The population at T0 was divided into 3 categories, according to the baseline hs-CRP levels. Higher hs-CRP levels were associated with significantly higher prevalence of overweight/obesity, body mass index (BMI) z-score and central adiposity indices (P values all
AB - Background--Whereas cross-sectional studies have shown that obesity is associated with increased C-reactive protein (CRP) levels in children, little is known about the impact of low-grade inflammation on body mass changes during growth. Methods and Results--We assessed cross-sectionally and longitudinally the association of high-sensitivity (hs)-CRP levels with overweight/obesity and related cardiometabolic risk factors in the Identification and prevention of Dietary-and lifestyle-induced health Effects in Children and InfantS (IDEFICS) cohort. 16 224 children from 8 European countries (2 to 9 years) were recruited during the baseline survey (T0). After the exclusion of 7187 children because of missing hs-CRP measurements and 2421 because of drug use during the previous week, the analysis was performed on 6616 children (Boys=3347; Girls=3269; age=6.3±1.7 years). Of them, 4110 were reexamined 2 years later (T1). Anthropometric variables, blood pressure, hs-CRP, blood lipids, glucose and insulin were measured. The population at T0 was divided into 3 categories, according to the baseline hs-CRP levels. Higher hs-CRP levels were associated with significantly higher prevalence of overweight/obesity, body mass index (BMI) z-score and central adiposity indices (P values all
KW - C-reactive protein
KW - Inflammation
KW - Pediatric obesity
KW - Population
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U2 - 10.1161/JAHA.113.000101
DO - 10.1161/JAHA.113.000101
M3 - Article
C2 - 23744403
AN - SCOPUS:84891404052
VL - 2
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
SN - 2047-9980
IS - 3
M1 - e000101
ER -