TY - JOUR
T1 - High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations
AU - Ceccherini-Silberstein, Francesca
AU - Gago, Federico
AU - Santoro, Maria
AU - Gori, Caterina
AU - Svicher, Valentina
AU - Rodríguez-Barrios, Fátima
AU - D'Arrigo, Roberta
AU - Ciccozzi, Massimo
AU - Bertoli, Ada
AU - D'Arminio Monforte, Antonella
AU - Baizarini, Jan
AU - Antinori, Andrea
AU - Perno, Carlo Federico
PY - 2005/8
Y1 - 2005/8
N2 - To define the extent of sequence conservation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) in vivo, the first 320 amino acids of RT obtained from 2,236 plasma-derived samples from a well-defined cohort of 1,704 HIV-1-infected individuals (457 drug naïve and 1,247 drug treated) were analyzed and examined in structural terms. In naïve patients, 233 out of these 320 residues (73%) were conserved (
AB - To define the extent of sequence conservation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) in vivo, the first 320 amino acids of RT obtained from 2,236 plasma-derived samples from a well-defined cohort of 1,704 HIV-1-infected individuals (457 drug naïve and 1,247 drug treated) were analyzed and examined in structural terms. In naïve patients, 233 out of these 320 residues (73%) were conserved (
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U2 - 10.1128/JVI.79.16.10718-10729.2005
DO - 10.1128/JVI.79.16.10718-10729.2005
M3 - Article
C2 - 16051864
AN - SCOPUS:23244465516
VL - 79
SP - 10718
EP - 10729
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 16
ER -