High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations

Francesca Ceccherini-Silberstein; Federico Gago; Maria Santoro; Caterina Gori; Valentina Svicher; Fátima Rodríguez-Barrios; Roberta D'Arrigo; Massimo Ciccozzi; Ada Bertoli; Antonella D'Arminio Monforte; Jan Baizarini; Andrea Antinori; Carlo Federico Perno

doi:10.1128/JVI.79.16.10718-10729.2005

High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations

Francesca Ceccherini-Silberstein, Federico Gago, Maria Santoro, Caterina Gori, Valentina Svicher, Fátima Rodríguez-Barrios, Roberta D'Arrigo, Massimo Ciccozzi, Ada Bertoli, Antonella D'Arminio Monforte, Jan Baizarini, Andrea Antinori, Carlo Federico Perno

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

To define the extent of sequence conservation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) in vivo, the first 320 amino acids of RT obtained from 2,236 plasma-derived samples from a well-defined cohort of 1,704 HIV-1-infected individuals (457 drug naïve and 1,247 drug treated) were analyzed and examined in structural terms. In naïve patients, 233 out of these 320 residues (73%) were conserved (

Original language	English
Pages (from-to)	10718-10729
Number of pages	12
Journal	Journal of Virology
Volume	79
Issue number	16
DOIs	https://doi.org/10.1128/JVI.79.16.10718-10729.2005
Publication status	Published - Aug 2005

ASJC Scopus subject areas

Immunology

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Ceccherini-Silberstein, F., Gago, F., Santoro, M., Gori, C., Svicher, V., Rodríguez-Barrios, F., D'Arrigo, R., Ciccozzi, M., Bertoli, A., D'Arminio Monforte, A., Baizarini, J., Antinori, A., & Perno, C. F. (2005). High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations. Journal of Virology, 79(16), 10718-10729. https://doi.org/10.1128/JVI.79.16.10718-10729.2005

High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations. / Ceccherini-Silberstein, Francesca; Gago, Federico; Santoro, Maria; Gori, Caterina; Svicher, Valentina; Rodríguez-Barrios, Fátima; D'Arrigo, Roberta; Ciccozzi, Massimo; Bertoli, Ada; D'Arminio Monforte, Antonella; Baizarini, Jan; Antinori, Andrea ; Perno, Carlo Federico.

In: Journal of Virology, Vol. 79, No. 16, 08.2005, p. 10718-10729.

Research output: Contribution to journal › Article › peer-review

Ceccherini-Silberstein, F, Gago, F, Santoro, M, Gori, C, Svicher, V, Rodríguez-Barrios, F, D'Arrigo, R, Ciccozzi, M, Bertoli, A, D'Arminio Monforte, A, Baizarini, J, Antinori, A & Perno, CF 2005, 'High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations', Journal of Virology, vol. 79, no. 16, pp. 10718-10729. https://doi.org/10.1128/JVI.79.16.10718-10729.2005

Ceccherini-Silberstein, Francesca ; Gago, Federico ; Santoro, Maria ; Gori, Caterina ; Svicher, Valentina ; Rodríguez-Barrios, Fátima ; D'Arrigo, Roberta ; Ciccozzi, Massimo ; Bertoli, Ada ; D'Arminio Monforte, Antonella ; Baizarini, Jan ; Antinori, Andrea ; Perno, Carlo Federico. / High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations. In: Journal of Virology. 2005 ; Vol. 79, No. 16. pp. 10718-10729.

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abstract = "To define the extent of sequence conservation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) in vivo, the first 320 amino acids of RT obtained from 2,236 plasma-derived samples from a well-defined cohort of 1,704 HIV-1-infected individuals (457 drug na{\"i}ve and 1,247 drug treated) were analyzed and examined in structural terms. In na{\"i}ve patients, 233 out of these 320 residues (73%) were conserved (",

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