High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations

Francesca Ceccherini-Silberstein, Federico Gago, Maria Santoro, Caterina Gori, Valentina Svicher, Fátima Rodríguez-Barrios, Roberta D'Arrigo, Massimo Ciccozzi, Ada Bertoli, Antonella D'Arminio Monforte, Jan Baizarini, Andrea Antinori, Carlo Federico Perno

Research output: Contribution to journalArticlepeer-review

Abstract

To define the extent of sequence conservation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) in vivo, the first 320 amino acids of RT obtained from 2,236 plasma-derived samples from a well-defined cohort of 1,704 HIV-1-infected individuals (457 drug naïve and 1,247 drug treated) were analyzed and examined in structural terms. In naïve patients, 233 out of these 320 residues (73%) were conserved (

Original languageEnglish
Pages (from-to)10718-10729
Number of pages12
JournalJournal of Virology
Volume79
Issue number16
DOIs
Publication statusPublished - Aug 2005

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations'. Together they form a unique fingerprint.

Cite this