High Seroprevalence of Human Herpesvirus 8 (HHV-8) in HIV-1-Infected Pregnant Women of Southeastern Italy: Association with Injection Drug Use and Hepatitis C Virus Infection

Josè Ramòn Fiore, Anna Volpe, Maria Alessandra Tosatti, Lucia De Valentin, Anna Favia, Maria Chironna, Andrea Lisco, Antonella Vimercati, Gioacchino Angarano, Luigi Chieco-Bianchi, Maria Luisa Calabrò

Research output: Contribution to journalArticle

Abstract

The seroprevalence of human herpesvirus 8 (HHV-8) in a group of HIV-1-infected pregnant women and in mother-child pairs from Southeastern Italy (Apulia) was determined. Blood was collected from 49 HIV-1-infected women during pregnancy or at delivery as well as from their children. Samples were analysed for the presence of antibodies to the latency-associated nuclear antigen and a structural antigen encoded by open reading frame 65. The presence of antibodies to hepatitis C virus (HCV) was also determined. Nineteen women (38.7%) were found to be positive for HHV-8 antibodies to at least one of the two antigens, and 21 (42.9%) for HCV antibodies. HHV-8 antibodies were more common in injecting drug users (56.3%) than in women infected through heterosexual intercourse (30.3%). HCV antibodies were significantly more prevalent in HHV-8-seropositive (66.7%) than HHV-8-seronegative (29%) women. Thirteen children born to HIV-1/HHV-8 co-infected women were HHV-8-seroreactive, with a variable pattern of reactivity to the analysed antigens. Follow-up of children showed a prolonged persistence of antibodies, in two cases for more than 12 months. This study has provided serological evidence for a high rate of HHV-8 infection in HIV-1-infected women in the Apulia region, and has identified a possible association between HHV-8 infection, past use of injection drugs and HCV infection. Parenteral transmission may, therefore, be a mode of virus spread.

Original languageEnglish
Pages (from-to)656-660
Number of pages5
JournalJournal of Medical Virology
Volume72
Issue number4
DOIs
Publication statusPublished - Apr 2004

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Keywords

  • HCV
  • HHV-8
  • Mother-child pairs
  • Risk factors
  • Transmission

ASJC Scopus subject areas

  • Virology

Cite this

Fiore, J. R., Volpe, A., Tosatti, M. A., De Valentin, L., Favia, A., Chironna, M., Lisco, A., Vimercati, A., Angarano, G., Chieco-Bianchi, L., & Calabrò, M. L. (2004). High Seroprevalence of Human Herpesvirus 8 (HHV-8) in HIV-1-Infected Pregnant Women of Southeastern Italy: Association with Injection Drug Use and Hepatitis C Virus Infection. Journal of Medical Virology, 72(4), 656-660. https://doi.org/10.1002/jmv.20042