High serum leptin in patients with chronic graft-versus-host disease after hematopoietic stem cell transplantation

Libose Tauchmanovà, Giuseppe Matarese, Carlo Carella, Gennaro De Rosa, Bianca Serio, Patrizia Ricci, Gaetano Lombardi, Bruno Rotoli, Annamaria Colao, Carmine Selleri

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background. Increased serum leptin has been described after various organ transplants, with a mechanism that is still unclear. Methods. We measured serum leptin in 60 patients before and after allogeneic (allo) or autologous (auto) stem cell transplant (SCT) and in 60 healthy controls, matched for age and body mass index (BMI). Results. Serum leptin was higher in patients after SCT than before and in controls. Leptin production was higher after allo- than after auto-SCT; the presence of chronic graft-versus-host disease (cGVHD) was associated with the highest values. The physiological correlation with BMI was lost in the allogeneic setting, indicating a strong influence of factors other than the nutritional status on circulating leptin. No relationship was found between serum leptin levels and time from transplant, age, cortisol, C-reactive protein, and T-lymphocyte CD4-to-CD8 ratio. Among the cytokines secreted by type-1/type-2 T-helper lymphocytes, only serum interferon-gamma significantly correlated with serum leptin levels. Anti-leptin blocking antibodies partially inhibited T-cell activation in mixed lymphocyte reaction, suggesting a link between leptin and T-lymphocyte activation in the allo-SCT setting. Conclusion. Taken together, these findings suggest that increased serum leptin concentrations may contribute to T-cell activation during development of cGVHD.

Original languageEnglish
Pages (from-to)1376-1383
Number of pages8
JournalTransplantation
Volume78
Issue number9
DOIs
Publication statusPublished - Nov 15 2004

Fingerprint

Hematopoietic Stem Cell Transplantation
Graft vs Host Disease
Leptin
Serum
Transplants
Stem Cells
T-Lymphocytes
Body Mass Index
CD4-CD8 Ratio
Mixed Lymphocyte Culture Test
Blocking Antibodies
Lymphocyte Activation
Helper-Inducer T-Lymphocytes
Nutritional Status
C-Reactive Protein
Interferon-gamma
Hydrocortisone
Cytokines

Keywords

  • Allogeneic stem cell transplant
  • Chronic graft-versus-host disease
  • Interferon-gamma
  • Leptin

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Tauchmanovà, L., Matarese, G., Carella, C., De Rosa, G., Serio, B., Ricci, P., ... Selleri, C. (2004). High serum leptin in patients with chronic graft-versus-host disease after hematopoietic stem cell transplantation. Transplantation, 78(9), 1376-1383. https://doi.org/10.1097/01.TP.0000140485.20848.B7

High serum leptin in patients with chronic graft-versus-host disease after hematopoietic stem cell transplantation. / Tauchmanovà, Libose; Matarese, Giuseppe; Carella, Carlo; De Rosa, Gennaro; Serio, Bianca; Ricci, Patrizia; Lombardi, Gaetano; Rotoli, Bruno; Colao, Annamaria; Selleri, Carmine.

In: Transplantation, Vol. 78, No. 9, 15.11.2004, p. 1376-1383.

Research output: Contribution to journalArticle

Tauchmanovà, L, Matarese, G, Carella, C, De Rosa, G, Serio, B, Ricci, P, Lombardi, G, Rotoli, B, Colao, A & Selleri, C 2004, 'High serum leptin in patients with chronic graft-versus-host disease after hematopoietic stem cell transplantation', Transplantation, vol. 78, no. 9, pp. 1376-1383. https://doi.org/10.1097/01.TP.0000140485.20848.B7
Tauchmanovà, Libose ; Matarese, Giuseppe ; Carella, Carlo ; De Rosa, Gennaro ; Serio, Bianca ; Ricci, Patrizia ; Lombardi, Gaetano ; Rotoli, Bruno ; Colao, Annamaria ; Selleri, Carmine. / High serum leptin in patients with chronic graft-versus-host disease after hematopoietic stem cell transplantation. In: Transplantation. 2004 ; Vol. 78, No. 9. pp. 1376-1383.
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