High serum levels of soluble CD40-L in patients with undifferentiated nasopharyngeal carcinoma: Pathogenic and clinical relevance

Laura Caggiari, Massimo Guidoboni, Emanuela Vaccher, Luigi Barzan, Giovanni Franchin, Annunziata Gloghini, Debora Martorelli, Paola Zancai, Maria Teresa Bortolin, Mario Mazzucato, Diego Serraino, Antonino Carbone, Paolo De Paoli, Riccardo Dolcetti

Research output: Contribution to journalArticle

Abstract

Background: Engagement of CD40 promotes survival of undifferentiated nasopharyngeal carcinoma (UNPC) cells and similar effects are induced by the EBV oncoprotein LMP-1 that is expressed in a fraction of cases. Considering that CD40 may be activated also by the soluble isoform of CD40L (sCD40L), we investigated the serum levels of sCD40L in a series of 61 UNPC patients from Italy, a non-endemic area for this disease. Results: At diagnosis, serum samples of UNPC patients contained significantly higher levels of sCD40L than agematched healthy controls (p <0.001). High levels of sCD40L (i.e., > 18 ng/ml) were more frequently found in patients + lymphoid cells admixed to neoplastic UNPC cells were detected in cases with high serum levels of sCD40L, suggesting that sCD40L is probably produced within the tumor mass. Conclusion: sCD40L may contribute to CD40 activation in UNPC cells, particularly of LMP-1-negative cases, further supporting the crucial role of CD40 signalling in the pathogenesis of UNPC. sCD40L levels may be useful to identify UNPC patients with occult distant metastases at presentation.

Original languageEnglish
Article number5
JournalInfectious Agents and Cancer
Volume2
Issue number1
DOIs
Publication statusPublished - 2007

ASJC Scopus subject areas

  • Infectious Diseases
  • Oncology
  • Epidemiology
  • Cancer Research

Fingerprint Dive into the research topics of 'High serum levels of soluble CD40-L in patients with undifferentiated nasopharyngeal carcinoma: Pathogenic and clinical relevance'. Together they form a unique fingerprint.

  • Cite this