High serum levels of tumour necrosis factor-α and interleukin-8 in severe asthma: Markers of systemic inflammation?

M. Silvestri, M. Bontempelli, M. Giacomelli, M. Malerba, G. A. Rossi, A. Di Stefano, A. Rossi, F. L M Ricciardolo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Severe asthma is characterized by elevated levels of pro-inflammatory cytokines and neutrophilic inflammation in the airways. Blood cytokines, markers of 'systemic' inflammation, may be a feature of amplified inflammation in severe asthma. Objective: To detect differences in IL-8, TNF-α, IL-16 and IL-13 levels in the serum(s) of stable severe and mild-moderate asthmatics related to blood leucocytes proportion, airway calibre and exhaled nitric oxide (NO) levels. Methods: We assessed cytokine serum levels by ELISA and blood leucocyte counts by an alkaline peroxidase method in 20 healthy controls, 22 mild-moderate [forced expiratory volume in 1 s (FEV 1)(%pred): 89±3] and 14 severe asthmatics [FEV 1(%pred): 49±2]. Results: IL-8 and TNF-α levels were higher in severe asthmatics than in mild-moderate asthmatics or in controls (P

Original languageEnglish
Pages (from-to)1373-1381
Number of pages9
JournalClinical and Experimental Allergy
Volume36
Issue number11
DOIs
Publication statusPublished - Nov 2006

Keywords

  • Asthma severity
  • IL-8
  • Nitric oxide
  • TNF-α

ASJC Scopus subject areas

  • Immunology

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