Abstract
Among the graft materials that can be used clinically, xenografts are the most common. Xenografts are of bovine, porcine, or equine origin and require the complete removal of proteins to avoid immunologic problems and the risk of transmission of prions, viruses, etc. Protein destruction can be achieved by a chemical procedure using organic solvents and heat treatment. After this process, a carbonated hydroxyapatite similar to human bone remains. The aim of this case report is to investigate the bone formation in a sinus augmentation procedure using a high temperature-treated bovine porous hydroxyapatite. A 58-year-old woman underwent bilateral sinus augmentation using this biomaterial. After 9 months, during stage-two surgery, two core biopsy specimens were retrieved and treated to obtain thin ground undecalcified sections. Microscopically, newly formed bone was present at the interface with most particles. The major portion of the particles appeared to be completely lined and surrounded by bone. No obvious signs of resorption were present on the biomaterial surface. No gaps or connective tissue were present at the bone-biomaterial interface. No inflammatory infiltrate or fibrous encapsulation of the particles was present. Histomorphometry showed that the percentages of newly formed bone, residual grafted particles, and marrow spaces were 25.1% ± 2.3%, 37.3% ± 1.1%, and 38.5% ± 3.1%, respectively. The excellent properties demonstrated by Endobon are probably a result of its particular hydroxyapatite porous microstructure with a high percentage of interconnected micropores that promote the ingrowth of osteogenic cells and vessels, making graft integration easier and faster.
| Original language | English |
|---|---|
| Pages (from-to) | 295-301 |
| Number of pages | 7 |
| Journal | The International journal of periodontics & restorative dentistry |
| Volume | 32 |
| Issue number | 3 |
| Publication status | Published - Jun 2012 |
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ASJC Scopus subject areas
- Oral Surgery
- Periodontics
Cite this
High temperature-treated bovine porous hydroxyapatite in sinus augmentation procedures : a case report. / Testori, Tiziano; Iezzi, Giovanna; Manzon, Licia; Fratto, Giovanni; Piattelli, Adriano; Weinstein, Roberto L.
In: The International journal of periodontics & restorative dentistry, Vol. 32, No. 3, 06.2012, p. 295-301.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High temperature-treated bovine porous hydroxyapatite in sinus augmentation procedures
T2 - a case report.
AU - Testori, Tiziano
AU - Iezzi, Giovanna
AU - Manzon, Licia
AU - Fratto, Giovanni
AU - Piattelli, Adriano
AU - Weinstein, Roberto L.
PY - 2012/6
Y1 - 2012/6
N2 - Among the graft materials that can be used clinically, xenografts are the most common. Xenografts are of bovine, porcine, or equine origin and require the complete removal of proteins to avoid immunologic problems and the risk of transmission of prions, viruses, etc. Protein destruction can be achieved by a chemical procedure using organic solvents and heat treatment. After this process, a carbonated hydroxyapatite similar to human bone remains. The aim of this case report is to investigate the bone formation in a sinus augmentation procedure using a high temperature-treated bovine porous hydroxyapatite. A 58-year-old woman underwent bilateral sinus augmentation using this biomaterial. After 9 months, during stage-two surgery, two core biopsy specimens were retrieved and treated to obtain thin ground undecalcified sections. Microscopically, newly formed bone was present at the interface with most particles. The major portion of the particles appeared to be completely lined and surrounded by bone. No obvious signs of resorption were present on the biomaterial surface. No gaps or connective tissue were present at the bone-biomaterial interface. No inflammatory infiltrate or fibrous encapsulation of the particles was present. Histomorphometry showed that the percentages of newly formed bone, residual grafted particles, and marrow spaces were 25.1% ± 2.3%, 37.3% ± 1.1%, and 38.5% ± 3.1%, respectively. The excellent properties demonstrated by Endobon are probably a result of its particular hydroxyapatite porous microstructure with a high percentage of interconnected micropores that promote the ingrowth of osteogenic cells and vessels, making graft integration easier and faster.
AB - Among the graft materials that can be used clinically, xenografts are the most common. Xenografts are of bovine, porcine, or equine origin and require the complete removal of proteins to avoid immunologic problems and the risk of transmission of prions, viruses, etc. Protein destruction can be achieved by a chemical procedure using organic solvents and heat treatment. After this process, a carbonated hydroxyapatite similar to human bone remains. The aim of this case report is to investigate the bone formation in a sinus augmentation procedure using a high temperature-treated bovine porous hydroxyapatite. A 58-year-old woman underwent bilateral sinus augmentation using this biomaterial. After 9 months, during stage-two surgery, two core biopsy specimens were retrieved and treated to obtain thin ground undecalcified sections. Microscopically, newly formed bone was present at the interface with most particles. The major portion of the particles appeared to be completely lined and surrounded by bone. No obvious signs of resorption were present on the biomaterial surface. No gaps or connective tissue were present at the bone-biomaterial interface. No inflammatory infiltrate or fibrous encapsulation of the particles was present. Histomorphometry showed that the percentages of newly formed bone, residual grafted particles, and marrow spaces were 25.1% ± 2.3%, 37.3% ± 1.1%, and 38.5% ± 3.1%, respectively. The excellent properties demonstrated by Endobon are probably a result of its particular hydroxyapatite porous microstructure with a high percentage of interconnected micropores that promote the ingrowth of osteogenic cells and vessels, making graft integration easier and faster.
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UR - http://www.scopus.com/inward/citedby.url?scp=84864873115&partnerID=8YFLogxK
M3 - Article
C2 - 22408774
AN - SCOPUS:84864873115
VL - 32
SP - 295
EP - 301
JO - International Journal of Periodontics and Restorative Dentistry
JF - International Journal of Periodontics and Restorative Dentistry
SN - 0198-7569
IS - 3
ER -