High-Throughput analysis of the drug mode of action of PB28, MC18 and MC70, three cyclohexylpiperazine derivative new molecules

Vitoantonio Bevilacqua, Paolo Pannarale, Giuseppe Mastronardi, Amalia Azzariti, Stefania Tommasi, Filippo Menolascina, Francesco Iorio, Diego Di Bernardo, Angelo Paradiso, Nicola A. Colabufo, Francesco Berardi, Roberto Perrone, Roberto Tagliaferri

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Objective: This work explores the mode of action of PB28, MC70 and MC18 three molecules that showed anti-tumoral properties by arresting cellular growth and inhibiting glycoprotein P. Methods: Here we conduct a microarray-based study and analyze the expression patterns associated with the action of drugs. An ontology based analysis has been conducted, and the individuated cellular processes have been analyzed with gene networks, examining the interactions among genes. A clustering analysis revealed mechanisms shared with other drugs. Results: The results indicate that this compounds have side effects that include inflammatory response and fever, induced by the interleukin signaling pathway. Other evidences related with known effects of the compounds were highlighted. Conclusions: The results indicate that the direct effects could be reached at a post-transcriptional level of P-gp or through other targets, further studies will address these hypothesis. The prediction of side effects will be useful in subsequent in vivo experiments.

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages1085-1092
Number of pages8
Volume5227 LNAI
DOIs
Publication statusPublished - 2008
Event4th International Conference on Intelligent Computing, ICIC 2008 - Shanghai, China
Duration: Sep 15 2008Sep 18 2008

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume5227 LNAI
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other4th International Conference on Intelligent Computing, ICIC 2008
CountryChina
CityShanghai
Period9/15/089/18/08

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

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    Bevilacqua, V., Pannarale, P., Mastronardi, G., Azzariti, A., Tommasi, S., Menolascina, F., Iorio, F., Di Bernardo, D., Paradiso, A., Colabufo, N. A., Berardi, F., Perrone, R., & Tagliaferri, R. (2008). High-Throughput analysis of the drug mode of action of PB28, MC18 and MC70, three cyclohexylpiperazine derivative new molecules. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 5227 LNAI, pp. 1085-1092). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 5227 LNAI). https://doi.org/10.1007/978-3-540-85984-0_130