High torquetenovirus loads are correlated with bronchiectasis and peripheral airflow limitation in children

Massimo Pifferi, Fabrizio Maggi, Davide Caramella, Emanuela De Marco, Elisabetta Andreoli, Silvia Meschi, Pierantonio MacChia, Mauro Bendinelli, Attilio L. Boner

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: The aim of the study was to evaluate the prevalence of torquetenovirus (TTV) infection in a group of children with recurrent lower respiratory tract infections and radiologic evidence of bronchiectasis. Correlations between TTV loads and severity of bronchiectasis and between TTV loads and lung function were evaluated. METHODS: In 38 subjects, high-resolution computed tomography (HRCT) and plasma tests for TTV detection and quantification were done. In 21/38 subjects, spirometry was also performed. RESULTS: TTV was found in 31/38 (81.6%) patients. The correlation between TTV loads and severity of bronchiectasis was statistically significant (r = 0.548; P = 0.01). TTV loads showed inverse correlation with FEF25-75% (r = -0.541; P = 0.011), and FEF25-75%/FVC (r = -0.512; P = 0.018). Inverse correlation was found also between severity of bronchiectasis and functional lung parameters: FEF25-75% (r = -0.635; P = 0.002), FEV1/FVC (r = -0.541; P = 0.011), and FEF25-75%/FVC (r = -0.645; P = 0.002). CONCLUSIONS: This study demonstrated the high prevalence of TTV infection in children with bronchiectasis. Moreover, we have shown a significant correlation between TTV loads and airflow limitation within the peripheral airways, as well as between severity of bronchiectasis and decrease of lung function.

Original languageEnglish
Pages (from-to)804-808
Number of pages5
JournalPediatric Infectious Disease Journal
Volume25
Issue number9
DOIs
Publication statusPublished - Sep 2006

Keywords

  • Emergent viruses
  • High-resolution computed tomography
  • Lung function

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

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