TY - JOUR
T1 - High troponin levels in patients hospitalized for coronavirus disease 2019: a maker or a marker of prognosis?
AU - Ghio, Stefano
AU - Montalto, Claudio
AU - Pagnesi, Matteo
AU - Lupi, Laura
AU - Cappelletti, Alberto
AU - Baldetti, Luca
AU - Baldi, Enrico
AU - Lombardi, Carlo
AU - Metra, Marco
AU - Perlini, Stefano
AU - Oltrona Visconti, Luigi
PY - 2021/11/1
Y1 - 2021/11/1
N2 - AIMS: Controversial data have been published regarding the prognostic role of cardiac troponins in patients who need hospitalization because of coronavirus disease 2019 (COVID-19). The aim of the study was to assess the role of high-sensitivity troponin plasma levels and of respiratory function at admission on all-cause deaths in unselected patients hospitalized because of COVID-19. METHODS: We pooled individual patient data from observational studies that assessed all-cause mortality of unselected patients hospitalized for COVID-19. The individual data of 722 patients were included. The ratio of partial pressure arterial oxygen to fraction of inspired oxygen (PaO2/FiO2) and high-sensitivity troponins was reported at admission in all patients. This meta-analysis was registered on PROSPERO (CRD42020213209). RESULTS: After a median follow-up of 14 days, 180 deaths were observed. At multivariable regression analysis, age [hazard ratio (HR) 1.083, 95% confidence interval (CI) 1.061-1.105, P
AB - AIMS: Controversial data have been published regarding the prognostic role of cardiac troponins in patients who need hospitalization because of coronavirus disease 2019 (COVID-19). The aim of the study was to assess the role of high-sensitivity troponin plasma levels and of respiratory function at admission on all-cause deaths in unselected patients hospitalized because of COVID-19. METHODS: We pooled individual patient data from observational studies that assessed all-cause mortality of unselected patients hospitalized for COVID-19. The individual data of 722 patients were included. The ratio of partial pressure arterial oxygen to fraction of inspired oxygen (PaO2/FiO2) and high-sensitivity troponins was reported at admission in all patients. This meta-analysis was registered on PROSPERO (CRD42020213209). RESULTS: After a median follow-up of 14 days, 180 deaths were observed. At multivariable regression analysis, age [hazard ratio (HR) 1.083, 95% confidence interval (CI) 1.061-1.105, P
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U2 - 10.2459/JCM.0000000000001249
DO - 10.2459/JCM.0000000000001249
M3 - Article
C2 - 34519287
AN - SCOPUS:85118096111
VL - 22
SP - 828
EP - 831
JO - J Cardiovasc Med (Hagerstown)
JF - J Cardiovasc Med (Hagerstown)
SN - 1558-2035
IS - 11
ER -