High troponin levels in patients hospitalized for coronavirus disease 2019: a maker or a marker of prognosis?

Stefano Ghio, Claudio Montalto, Matteo Pagnesi, Laura Lupi, Alberto Cappelletti, Luca Baldetti, Enrico Baldi, Carlo Lombardi, Marco Metra, Stefano Perlini, Luigi Oltrona Visconti

Research output: Contribution to journalArticlepeer-review

Abstract

AIMS: Controversial data have been published regarding the prognostic role of cardiac troponins in patients who need hospitalization because of coronavirus disease 2019 (COVID-19). The aim of the study was to assess the role of high-sensitivity troponin plasma levels and of respiratory function at admission on all-cause deaths in unselected patients hospitalized because of COVID-19. METHODS: We pooled individual patient data from observational studies that assessed all-cause mortality of unselected patients hospitalized for COVID-19. The individual data of 722 patients were included. The ratio of partial pressure arterial oxygen to fraction of inspired oxygen (PaO2/FiO2) and high-sensitivity troponins was reported at admission in all patients. This meta-analysis was registered on PROSPERO (CRD42020213209). RESULTS: After a median follow-up of 14 days, 180 deaths were observed. At multivariable regression analysis, age [hazard ratio (HR) 1.083, 95% confidence interval (CI) 1.061-1.105, P 
Original languageEnglish
Pages (from-to)828-831
Number of pages4
JournalJ Cardiovasc Med (Hagerstown)
Volume22
Issue number11
DOIs
Publication statusPublished - Nov 1 2021

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