High tumor necrosis factor-α in levels in cerebrospinal fluid of cobalamin-deficient patients

Giuseppe Scalabrino, Marinella Carpo, Fabrizia Bamonti, Simona Pizzinelli, Carla D'Avino, Nereo Bresolin, Giuseppe Meucci, Vittorio Martinelli, Gian Carlo Comi, Maddalena Peracchi

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Abstract

We studied 14 patients with neurological manifestations of subacute combined degeneration (SCD) and 40 control patients not cobalamin (Cbl)-deficient. The cerebrospinal fluid (CSF) markers of Cbl deficiency (Cbl and total homocysteine [tHCYS] levels) and the CSF levels of tumor necrosis factor (TNF)-α and epidermal growth factor (EGF) were measured. Significantly higher levels of tHCYS and TNF-α, and significantly lower levels of Cbl and EGF were found in the SCD patients. In human CSF, as in human serum and the rat central nervous system, decreased Cbl concentrations are concomitant with an increase in TNF-α and a decrease in EGF-levels.

Original languageEnglish
Pages (from-to)886-890
Number of pages5
JournalAnnals of Neurology
Volume56
Issue number6
DOIs
Publication statusPublished - Dec 2004

ASJC Scopus subject areas

  • Neuroscience(all)

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    Scalabrino, G., Carpo, M., Bamonti, F., Pizzinelli, S., D'Avino, C., Bresolin, N., Meucci, G., Martinelli, V., Comi, G. C., & Peracchi, M. (2004). High tumor necrosis factor-α in levels in cerebrospinal fluid of cobalamin-deficient patients. Annals of Neurology, 56(6), 886-890. https://doi.org/10.1002/ana.20325