High tumour necrosis factor-α levels are associated with exercise intolerance and neurohormonal activation in chronic heart failure patients

Mariantonietta Cicoira, Aidan P. Bolger, Wolfram Doehner, Mathias Rauchhaus, Constantinos Davos, Rakesh Sharma, Faisal O. Al-Nasser, Andrew J S Coats, Stefan D. Anker

Research output: Contribution to journalArticle

Abstract

Immune activation plays an important role in the progression of chronic heart failure (CHF). We sought to investigate whether different degrees of tumor necrosis factor-α (TNF-α) activation are associated with exercise intolerance, neurohormonal activation and alterations in muscle mass and function in patients with CHF without cardiac cachexia. Patients were divided into quartiles according to their TNF levels (first quartile: 0.98-4.90 pg/ml, second quartile: 5.00-6.60 pg/ml; third quartile 6.80-9.00 pg/ml; fourth quartile 9.80-32.00 pg/ml). Patients underwent cardio-pulmonary exercise testing, quadriceps muscle strength test, quadriceps fatigue test, and assessment of thigh muscle and fat cross-sectional area (CSA) by computerized tomography scanning. Patients in the highest TNF quartile had the lowest peak oxygen consumption [13.1 ( ± 4.1) ml/kg/min vs 18.1 ( ± 5.3), 18.8 ( ± 4.8) and 18.7 ( ± 5.6) ml/kg/min, P2) slope (P

Original languageEnglish
Pages (from-to)80-86
Number of pages7
JournalCytokine
Volume15
Issue number2
DOIs
Publication statusPublished - 2001

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Keywords

  • Chronic heart failure
  • Exercise intolerance
  • Neurohormonal activation
  • TNF-α

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy

Cite this

Cicoira, M., Bolger, A. P., Doehner, W., Rauchhaus, M., Davos, C., Sharma, R., Al-Nasser, F. O., Coats, A. J. S., & Anker, S. D. (2001). High tumour necrosis factor-α levels are associated with exercise intolerance and neurohormonal activation in chronic heart failure patients. Cytokine, 15(2), 80-86. https://doi.org/10.1006/cyto.2001.0918