High urine IP-10 levels associate with chronic HCV infection

Linda Petrone, Teresa Chiacchio, Valentina Vanini, Elisa Petruccioli, Gilda Cuzzi, Cristina Di Giacomo, Luigia Pucci, Marzia Montalbano, Raffaella Lionetti, Angela Testa, Daniele Lapa, Assunta Navarra, Ubaldo Visco-Comandini, Delia Goletti

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Independent of IL-28B polymorphisms, blood IP-10 is a promising biomarker for predicting therapy response in chronic HCV infection. Urine IP-10 has been proposed as a biomarker in tuberculosis, but to date, no urine biomarkers for HCV infection have been evaluated. In this cross-sectional study, we assessed whether IP-10 is detectable in the urine of chronically HCV-infected patients, and if so, whether urine IP-10 correlates with serum IP-10 and HCV-specific clinical parameters. Methods: IP-10 was measured by ELISA in serum and urine concomitantly taken from 38 HCV-viremic patients, 10 cured-HCV subjects and 11 healthy donors enrolled as controls. Results: The urine of HCV-viremic patients showed measurable amounts of IP-10, although significantly lower than in serum (p

Original languageEnglish
Pages (from-to)591-600
Number of pages10
JournalJournal of Infection
Volume68
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • Biomarkers
  • Cured-HCV subjects
  • HCV
  • IP-10
  • PnALT
  • Serum
  • SVR
  • Urine

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Medicine(all)

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