High urine IP-10 levels associate with chronic HCV infection

Research output: Contribution to journalArticle

Abstract

Objectives: Independent of IL-28B polymorphisms, blood IP-10 is a promising biomarker for predicting therapy response in chronic HCV infection. Urine IP-10 has been proposed as a biomarker in tuberculosis, but to date, no urine biomarkers for HCV infection have been evaluated. In this cross-sectional study, we assessed whether IP-10 is detectable in the urine of chronically HCV-infected patients, and if so, whether urine IP-10 correlates with serum IP-10 and HCV-specific clinical parameters. Methods: IP-10 was measured by ELISA in serum and urine concomitantly taken from 38 HCV-viremic patients, 10 cured-HCV subjects and 11 healthy donors enrolled as controls. Results: The urine of HCV-viremic patients showed measurable amounts of IP-10, although significantly lower than in serum (p

Original languageEnglish
Pages (from-to)591-600
Number of pages10
JournalJournal of Infection
Volume68
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • Biomarkers
  • Cured-HCV subjects
  • HCV
  • IP-10
  • PnALT
  • Serum
  • SVR
  • Urine

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Medicine(all)

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