High-voltage electroencephalogram spindles in rats, aging and 5-HT2 antagonism

Slavianka Moyanova, Lidia Kortenska, Roumen Kirov

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We examined the effects of serotonin-2 (5-hydroxytryptamine-2, 5-HT2) receptor antagonists on the so-called high-voltage spindles (HVS, electroencephalographic patterns, characterized by large amplitude rhythmic waves mainly in the α band), recorded from the frontal cortex of young, middle-aged and old freely-moving rats during waking immobility. The study was based on the assumption that the effects 5-HT2 receptor antagonists on the HVS activity depend on the age of rats, because there is evidence for an age-related in the 5-HT2 binding sites density. Four parameters of the electroencephalogram (EEG) were used to characterize the HVS activity: the square root-transformed EEG peak power in the at band, the frequency corresponding to this peak (both measured from the BEG power spectra using the fast Fourier transform), the HVS mean duration, and the HVS incidence (both measured from the EEG records). The EEG parameters were analyzed after i.p. administration of three 5-HT2 receptor antagonists: ketanserin, ritanserin and cyproheptadine. In young rats, the three drugs increased the α power, but did not change the α peak-corresponding frequency. Ketanserin and ritanserin did not change the HVS mean duration and HVS incidence, while cyproheptadine increased both parameters in young rats. In middle-aged and old untreated rats, the HVS activity was significantly increased. The three 5-HT2 antagonists did not change the HVS activity in aged rats, which could be clue to age-related suppression of the 5-HT2 receptor functions.

Original languageEnglish
Pages (from-to)55-63
Number of pages9
JournalBrain Research
Issue number1-2
Publication statusPublished - Mar 9 1998


  • 5-HT antagonist
  • Age
  • EEG
  • High-voltage spindle
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)


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