Higher growth, fat and fat-free masses correlate with larger cerebellar volumes in preterm infants at term

Giulia Paviotti, Angela De Cunto, Floriana Zennaro, Giulia Boz, Laura Travan, Gabriele Cont, Jenny Bua, Sergio Demarini

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3 Citations (Scopus)

Abstract

©2017 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd Aim: Smaller cerebellar volumes in very low-birthweight (VLBW) infants at term have been related to adverse cognitive outcomes, and this study evaluated whether these volumes were associated with a growth in body composition during hospital stays. Methods: We prospectively recruited 42 VLBW infants from an Italian neonatal unit between January 2013 and August 2015. Cerebellar volumes and body composition were measured by magnetic resonance imaging (MRI) and air-displacement plethysmography, respectively, at 40 weeks of gestational age and anthropometric and nutritional data were collected. We also included 20 term-born controls. Results: The mean gestational age and birthweight of the VLBW infants were 29.4 (±1.9) weeks and 1120 (±290) g. There was a positive correlation between cerebellar volumes and daily weight gain from birth to term (R 2 = 0.26, p = 0.001), weight (R 2 = 0.25, p = 0.001), length (R 2 = 0.16, p = 0.01), fat mass (R 2 = 0.15, p = 0.01) and fat-free mass at term (R 2 = 0.20, p = 0.003). In multiple regression analysis, daily weight gain, mechanical ventilation and postconceptional age at MRI were independently associated with cerebellar volumes. Anthropometric data and cerebellar volumes were similar between VLBW and control infants. Conclusion: Higher growth, higher fat mass and fat-free mass were associated with larger cerebellar volumes in VLBW infants at term.
Original languageEnglish
Pages (from-to)918-925
Number of pages8
JournalActa Paediatrica, International Journal of Paediatrics
Volume106
Issue number6
DOIs
Publication statusPublished - Jun 1 2017

Fingerprint

Premature Infants
Fats
Growth
Body Composition
Gestational Age
Weight Gain
Magnetic Resonance Imaging
Plethysmography
Nuclear Family
Artificial Respiration
Length of Stay
Air
Regression Analysis
Outcome Assessment (Health Care)
Parturition
Weights and Measures

Keywords

  • Body composition
  • Cerebellum
  • Preterm growth
  • Preterm nutrition
  • Very low-birthweight

Cite this

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title = "Higher growth, fat and fat-free masses correlate with larger cerebellar volumes in preterm infants at term",
abstract = "{\circledC}2017 Foundation Acta P{\ae}diatrica. Published by John Wiley & Sons Ltd Aim: Smaller cerebellar volumes in very low-birthweight (VLBW) infants at term have been related to adverse cognitive outcomes, and this study evaluated whether these volumes were associated with a growth in body composition during hospital stays. Methods: We prospectively recruited 42 VLBW infants from an Italian neonatal unit between January 2013 and August 2015. Cerebellar volumes and body composition were measured by magnetic resonance imaging (MRI) and air-displacement plethysmography, respectively, at 40 weeks of gestational age and anthropometric and nutritional data were collected. We also included 20 term-born controls. Results: The mean gestational age and birthweight of the VLBW infants were 29.4 (±1.9) weeks and 1120 (±290) g. There was a positive correlation between cerebellar volumes and daily weight gain from birth to term (R 2 = 0.26, p = 0.001), weight (R 2 = 0.25, p = 0.001), length (R 2 = 0.16, p = 0.01), fat mass (R 2 = 0.15, p = 0.01) and fat-free mass at term (R 2 = 0.20, p = 0.003). In multiple regression analysis, daily weight gain, mechanical ventilation and postconceptional age at MRI were independently associated with cerebellar volumes. Anthropometric data and cerebellar volumes were similar between VLBW and control infants. Conclusion: Higher growth, higher fat mass and fat-free mass were associated with larger cerebellar volumes in VLBW infants at term.",
keywords = "Body composition, Cerebellum, Preterm growth, Preterm nutrition, Very low-birthweight",
author = "Giulia Paviotti and {De Cunto}, Angela and Floriana Zennaro and Giulia Boz and Laura Travan and Gabriele Cont and Jenny Bua and Sergio Demarini",
year = "2017",
month = "6",
day = "1",
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language = "English",
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TY - JOUR

T1 - Higher growth, fat and fat-free masses correlate with larger cerebellar volumes in preterm infants at term

AU - Paviotti, Giulia

AU - De Cunto, Angela

AU - Zennaro, Floriana

AU - Boz, Giulia

AU - Travan, Laura

AU - Cont, Gabriele

AU - Bua, Jenny

AU - Demarini, Sergio

PY - 2017/6/1

Y1 - 2017/6/1

N2 - ©2017 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd Aim: Smaller cerebellar volumes in very low-birthweight (VLBW) infants at term have been related to adverse cognitive outcomes, and this study evaluated whether these volumes were associated with a growth in body composition during hospital stays. Methods: We prospectively recruited 42 VLBW infants from an Italian neonatal unit between January 2013 and August 2015. Cerebellar volumes and body composition were measured by magnetic resonance imaging (MRI) and air-displacement plethysmography, respectively, at 40 weeks of gestational age and anthropometric and nutritional data were collected. We also included 20 term-born controls. Results: The mean gestational age and birthweight of the VLBW infants were 29.4 (±1.9) weeks and 1120 (±290) g. There was a positive correlation between cerebellar volumes and daily weight gain from birth to term (R 2 = 0.26, p = 0.001), weight (R 2 = 0.25, p = 0.001), length (R 2 = 0.16, p = 0.01), fat mass (R 2 = 0.15, p = 0.01) and fat-free mass at term (R 2 = 0.20, p = 0.003). In multiple regression analysis, daily weight gain, mechanical ventilation and postconceptional age at MRI were independently associated with cerebellar volumes. Anthropometric data and cerebellar volumes were similar between VLBW and control infants. Conclusion: Higher growth, higher fat mass and fat-free mass were associated with larger cerebellar volumes in VLBW infants at term.

AB - ©2017 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd Aim: Smaller cerebellar volumes in very low-birthweight (VLBW) infants at term have been related to adverse cognitive outcomes, and this study evaluated whether these volumes were associated with a growth in body composition during hospital stays. Methods: We prospectively recruited 42 VLBW infants from an Italian neonatal unit between January 2013 and August 2015. Cerebellar volumes and body composition were measured by magnetic resonance imaging (MRI) and air-displacement plethysmography, respectively, at 40 weeks of gestational age and anthropometric and nutritional data were collected. We also included 20 term-born controls. Results: The mean gestational age and birthweight of the VLBW infants were 29.4 (±1.9) weeks and 1120 (±290) g. There was a positive correlation between cerebellar volumes and daily weight gain from birth to term (R 2 = 0.26, p = 0.001), weight (R 2 = 0.25, p = 0.001), length (R 2 = 0.16, p = 0.01), fat mass (R 2 = 0.15, p = 0.01) and fat-free mass at term (R 2 = 0.20, p = 0.003). In multiple regression analysis, daily weight gain, mechanical ventilation and postconceptional age at MRI were independently associated with cerebellar volumes. Anthropometric data and cerebellar volumes were similar between VLBW and control infants. Conclusion: Higher growth, higher fat mass and fat-free mass were associated with larger cerebellar volumes in VLBW infants at term.

KW - Body composition

KW - Cerebellum

KW - Preterm growth

KW - Preterm nutrition

KW - Very low-birthweight

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