Higher levels of HIV DNA in memory and naive CD4+ T cell subsets of viremic compared to non-viremic patients after 18 and 24 months of HAART

Fausto Baldanti, Stefania Paolucci, Roberto Gulminetti, Renato Maserati, Guglielmo Migliorinol, Angelo Panl, Franco Maggiolol, Giuditta Comolli, Antonella Chiesa, Giuseppe Gerna

Research output: Contribution to journalArticle

Abstract

The degree of infection of memory and naive CD4+ T cells in patients treated with HAART and with durable undetectable or detectable viral load in plasma was evaluated. The following two groups of patients were analyzed cross-sectionally: (i) patients with undetectable HIV RNA plasma levels during follow-up (responders); (ii) patients with no reduction or with rebound in HIV RNA levels during treatment (non-responders). Patients were examined following 6, 12, 18 and 24 months of HAART, respectively, by quantifying: (i) plasma HIV RNA load; (ii) CD4+ T cells; (iii) memory and naive CD4+ T cells; (iv) HIV DNA levels in memory and naive CD4+ T cells. HIV RNA plasma levels were significantly higher in non-responders vs responders at each time point (P + T cell counts as well as memory and naive CD4+ T cell levels were comparable in both viremic and non-viremic patients. However, higher HIV DNA values were observed in both memory and naive CD4+ T cells of non-responders vs responders after 18 and 24 months of HAART (P + T cells and a sustained high degree of infection of memory CD4+ T cells. Immunological reconstitution following HAART might potentially be hampered in viremic patients despite the absolute increase in CD4+ T cell counts.

Original languageEnglish
Pages (from-to)197-206
Number of pages10
JournalAntiviral Research
Volume50
Issue number3
DOIs
Publication statusPublished - 2001

Keywords

  • HAART
  • HIV DNA
  • Memory CD4 T cells
  • Naive CD4 T cells

ASJC Scopus subject areas

  • Virology
  • Pharmacology

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