Higher rate of early-onset preeclampsia in pregnancies following oocyte donation according to increasing maternal age

Bianca Masturzo, Daniela Di Martino, Federico Prefumo, Paolo Cavoretto, Chiara Germano, Gianluca Gennarelli, Enrica Roletti, Elisa Bottazzoli, Federica Fusè, Enrico Ferrazzi, Danila Morano, Antonio Farina

Research output: Contribution to journalReview article

Abstract

OBJECTIVE: To assess the influence of maternal age on the incidence of early-onset preeclampsia requiring delivery before 34 weeks of gestation in pregnancies obtained after oocyte donation. METHODS: We carried out a prospective cohort analysis of 431 single and twin pregnancies, admitted to 3 Tertiary Referral Hospital in Northern Italy between 2008 and 2017. The rate of early-onset PE was calculated and stratified according to maternal age (from 30 to 49 years). A reference population of 11,197 single pregnancies collected prospectively at the first trimester of pregnancy in the same geographic area of Italy and in same hospitals was used to calculate the expected incidence of early-onset PE. RESULTS: In women who delivered after 24 weeks of gestation, the rate of early-onset PE was much higher in oocyte-donation pregnancies, reaching 6.7% (29/431), than the expected rate of 0.5% of the cohort of reference. The mean early PE rate was 4.1% (10/242) in singletons and 10.1% (19/189) in twin pregnancies. According to maternal age, the rate of early PE was 1.16% and 3.12% at 30 years, and 4.98% and 13.14% at 49 years in single and twin pregnancies obtained after oocyte donation, respectively. CONCLUSION: Pregnancies obtained after oocyte donation delivering after 24 weeks had a higher risk of early-onset PE requiring delivery before 34 weeks of gestation, than the general population. The risk is directly correlated with the increase of maternal age and is also higher in twin pregnancies.

Original languageEnglish
Pages (from-to)861-867
Number of pages7
JournalArchives of Gynecology and Obstetrics
Volume300
Issue number4
DOIs
Publication statusPublished - Oct 1 2019

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Oocyte Donation
Maternal Age
Pre-Eclampsia
Twin Pregnancy
Pregnancy
Italy
Incidence
First Pregnancy Trimester
Tertiary Care Centers
Population
Cohort Studies

Keywords

  • Binary logistic regression
  • Early-onset preeclampsia
  • Maternal age-related risk
  • Oocyte-donor pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Masturzo, B., Di Martino, D., Prefumo, F., Cavoretto, P., Germano, C., Gennarelli, G., ... Farina, A. (2019). Higher rate of early-onset preeclampsia in pregnancies following oocyte donation according to increasing maternal age. Archives of Gynecology and Obstetrics, 300(4), 861-867. https://doi.org/10.1007/s00404-019-05291-w

Higher rate of early-onset preeclampsia in pregnancies following oocyte donation according to increasing maternal age. / Masturzo, Bianca; Di Martino, Daniela; Prefumo, Federico; Cavoretto, Paolo; Germano, Chiara; Gennarelli, Gianluca; Roletti, Enrica; Bottazzoli, Elisa; Fusè, Federica; Ferrazzi, Enrico; Morano, Danila; Farina, Antonio.

In: Archives of Gynecology and Obstetrics, Vol. 300, No. 4, 01.10.2019, p. 861-867.

Research output: Contribution to journalReview article

Masturzo, B, Di Martino, D, Prefumo, F, Cavoretto, P, Germano, C, Gennarelli, G, Roletti, E, Bottazzoli, E, Fusè, F, Ferrazzi, E, Morano, D & Farina, A 2019, 'Higher rate of early-onset preeclampsia in pregnancies following oocyte donation according to increasing maternal age', Archives of Gynecology and Obstetrics, vol. 300, no. 4, pp. 861-867. https://doi.org/10.1007/s00404-019-05291-w
Masturzo, Bianca ; Di Martino, Daniela ; Prefumo, Federico ; Cavoretto, Paolo ; Germano, Chiara ; Gennarelli, Gianluca ; Roletti, Enrica ; Bottazzoli, Elisa ; Fusè, Federica ; Ferrazzi, Enrico ; Morano, Danila ; Farina, Antonio. / Higher rate of early-onset preeclampsia in pregnancies following oocyte donation according to increasing maternal age. In: Archives of Gynecology and Obstetrics. 2019 ; Vol. 300, No. 4. pp. 861-867.
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abstract = "OBJECTIVE: To assess the influence of maternal age on the incidence of early-onset preeclampsia requiring delivery before 34 weeks of gestation in pregnancies obtained after oocyte donation. METHODS: We carried out a prospective cohort analysis of 431 single and twin pregnancies, admitted to 3 Tertiary Referral Hospital in Northern Italy between 2008 and 2017. The rate of early-onset PE was calculated and stratified according to maternal age (from 30 to 49 years). A reference population of 11,197 single pregnancies collected prospectively at the first trimester of pregnancy in the same geographic area of Italy and in same hospitals was used to calculate the expected incidence of early-onset PE. RESULTS: In women who delivered after 24 weeks of gestation, the rate of early-onset PE was much higher in oocyte-donation pregnancies, reaching 6.7{\%} (29/431), than the expected rate of 0.5{\%} of the cohort of reference. The mean early PE rate was 4.1{\%} (10/242) in singletons and 10.1{\%} (19/189) in twin pregnancies. According to maternal age, the rate of early PE was 1.16{\%} and 3.12{\%} at 30 years, and 4.98{\%} and 13.14{\%} at 49 years in single and twin pregnancies obtained after oocyte donation, respectively. CONCLUSION: Pregnancies obtained after oocyte donation delivering after 24 weeks had a higher risk of early-onset PE requiring delivery before 34 weeks of gestation, than the general population. The risk is directly correlated with the increase of maternal age and is also higher in twin pregnancies.",
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TY - JOUR

T1 - Higher rate of early-onset preeclampsia in pregnancies following oocyte donation according to increasing maternal age

AU - Masturzo, Bianca

AU - Di Martino, Daniela

AU - Prefumo, Federico

AU - Cavoretto, Paolo

AU - Germano, Chiara

AU - Gennarelli, Gianluca

AU - Roletti, Enrica

AU - Bottazzoli, Elisa

AU - Fusè, Federica

AU - Ferrazzi, Enrico

AU - Morano, Danila

AU - Farina, Antonio

PY - 2019/10/1

Y1 - 2019/10/1

N2 - OBJECTIVE: To assess the influence of maternal age on the incidence of early-onset preeclampsia requiring delivery before 34 weeks of gestation in pregnancies obtained after oocyte donation. METHODS: We carried out a prospective cohort analysis of 431 single and twin pregnancies, admitted to 3 Tertiary Referral Hospital in Northern Italy between 2008 and 2017. The rate of early-onset PE was calculated and stratified according to maternal age (from 30 to 49 years). A reference population of 11,197 single pregnancies collected prospectively at the first trimester of pregnancy in the same geographic area of Italy and in same hospitals was used to calculate the expected incidence of early-onset PE. RESULTS: In women who delivered after 24 weeks of gestation, the rate of early-onset PE was much higher in oocyte-donation pregnancies, reaching 6.7% (29/431), than the expected rate of 0.5% of the cohort of reference. The mean early PE rate was 4.1% (10/242) in singletons and 10.1% (19/189) in twin pregnancies. According to maternal age, the rate of early PE was 1.16% and 3.12% at 30 years, and 4.98% and 13.14% at 49 years in single and twin pregnancies obtained after oocyte donation, respectively. CONCLUSION: Pregnancies obtained after oocyte donation delivering after 24 weeks had a higher risk of early-onset PE requiring delivery before 34 weeks of gestation, than the general population. The risk is directly correlated with the increase of maternal age and is also higher in twin pregnancies.

AB - OBJECTIVE: To assess the influence of maternal age on the incidence of early-onset preeclampsia requiring delivery before 34 weeks of gestation in pregnancies obtained after oocyte donation. METHODS: We carried out a prospective cohort analysis of 431 single and twin pregnancies, admitted to 3 Tertiary Referral Hospital in Northern Italy between 2008 and 2017. The rate of early-onset PE was calculated and stratified according to maternal age (from 30 to 49 years). A reference population of 11,197 single pregnancies collected prospectively at the first trimester of pregnancy in the same geographic area of Italy and in same hospitals was used to calculate the expected incidence of early-onset PE. RESULTS: In women who delivered after 24 weeks of gestation, the rate of early-onset PE was much higher in oocyte-donation pregnancies, reaching 6.7% (29/431), than the expected rate of 0.5% of the cohort of reference. The mean early PE rate was 4.1% (10/242) in singletons and 10.1% (19/189) in twin pregnancies. According to maternal age, the rate of early PE was 1.16% and 3.12% at 30 years, and 4.98% and 13.14% at 49 years in single and twin pregnancies obtained after oocyte donation, respectively. CONCLUSION: Pregnancies obtained after oocyte donation delivering after 24 weeks had a higher risk of early-onset PE requiring delivery before 34 weeks of gestation, than the general population. The risk is directly correlated with the increase of maternal age and is also higher in twin pregnancies.

KW - Binary logistic regression

KW - Early-onset preeclampsia

KW - Maternal age-related risk

KW - Oocyte-donor pregnancy

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U2 - 10.1007/s00404-019-05291-w

DO - 10.1007/s00404-019-05291-w

M3 - Review article

C2 - 31520261

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VL - 300

SP - 861

EP - 867

JO - Archives of Gynecology and Obstetrics

JF - Archives of Gynecology and Obstetrics

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