Higher uric acid levels are associated with better functional recovery in elderly patients receiving cardiac rehabilitation

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Abstract

Background and aims: Whether uric acid (UA) serves as risk factor for cardiovascular diseases or as antioxidant defense has not yet been completely clarified. In this study we investigated the effects of UA on functional recovery in patients receiving cardiac rehabilitation. Methods and results: 306 patients, 209 men and 97 women, age range 25-87 years (mean 68±11), performed the 6-min walk test (6mWT) before and after the rehabilitation, and the increase in walking distance was considered as the outcome measure of the study. Baseline UA serum levels ranged from 1.0 to 10.9mg/dL (mean 5.2±1.7). As there was a significant (p=0.005) age*UA levels interaction, patients were divided into two subgroups, less then 65 years (n. 103, 68 men and 35 women, mean age 56±9) and 65 years or more (n. 203, 141 men and 62 women, mean age 74±5). After adjusting for relevant confounders, higher UA levels remained independent positive predictors of the increase in walking distance in older (p

Original languageEnglish
Pages (from-to)1210-1215
Number of pages6
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume23
Issue number12
DOIs
Publication statusPublished - 2013

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Uric Acid
Walking
Outcome Assessment (Health Care)
Cardiovascular Diseases
Rehabilitation
Antioxidants
Cardiac Rehabilitation
Serum

Keywords

  • Antioxidants
  • Cardiac rehabilitation
  • Elderly
  • Functional recovery
  • Uric acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

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abstract = "Background and aims: Whether uric acid (UA) serves as risk factor for cardiovascular diseases or as antioxidant defense has not yet been completely clarified. In this study we investigated the effects of UA on functional recovery in patients receiving cardiac rehabilitation. Methods and results: 306 patients, 209 men and 97 women, age range 25-87 years (mean 68±11), performed the 6-min walk test (6mWT) before and after the rehabilitation, and the increase in walking distance was considered as the outcome measure of the study. Baseline UA serum levels ranged from 1.0 to 10.9mg/dL (mean 5.2±1.7). As there was a significant (p=0.005) age*UA levels interaction, patients were divided into two subgroups, less then 65 years (n. 103, 68 men and 35 women, mean age 56±9) and 65 years or more (n. 203, 141 men and 62 women, mean age 74±5). After adjusting for relevant confounders, higher UA levels remained independent positive predictors of the increase in walking distance in older (p",
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author = "R. Molino-Lova and D. Prisco and G. Pasquini and F. Vannetti and A. Paperini and R. Zipoli and Luisi, {M. L E} and F. Cecchi and C. Macchi",
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AU - Molino-Lova, R.

AU - Prisco, D.

AU - Pasquini, G.

AU - Vannetti, F.

AU - Paperini, A.

AU - Zipoli, R.

AU - Luisi, M. L E

AU - Cecchi, F.

AU - Macchi, C.

PY - 2013

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N2 - Background and aims: Whether uric acid (UA) serves as risk factor for cardiovascular diseases or as antioxidant defense has not yet been completely clarified. In this study we investigated the effects of UA on functional recovery in patients receiving cardiac rehabilitation. Methods and results: 306 patients, 209 men and 97 women, age range 25-87 years (mean 68±11), performed the 6-min walk test (6mWT) before and after the rehabilitation, and the increase in walking distance was considered as the outcome measure of the study. Baseline UA serum levels ranged from 1.0 to 10.9mg/dL (mean 5.2±1.7). As there was a significant (p=0.005) age*UA levels interaction, patients were divided into two subgroups, less then 65 years (n. 103, 68 men and 35 women, mean age 56±9) and 65 years or more (n. 203, 141 men and 62 women, mean age 74±5). After adjusting for relevant confounders, higher UA levels remained independent positive predictors of the increase in walking distance in older (p

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