Highlights of mechanistic and therapeutic Cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology

Markus S. Anker, Stephan Von Haehling, Jochen Springer, MacIej Banach, Stefan D. Anker

Research output: Contribution to journalArticle

Abstract

Sarcopenia and cachexia are significant medical problems with a high diseaserelated burden in cardiovascular illness. Muscle wasting and weight loss are very frequent particularly in chronic heart failure and they relate to poor prognosis. Although clinically largely underestimated, the fields of cachexia and sarcopenia are of great relevance to cardiologists. In cachexia and sarcopenia a significant number of research publications related to basic science questions of muscle wasting and lipolysis were published between 2010 and 2012. Recently, the two processes of muscle wasting and lipolysis were found to be closely linked. Treatment research in pre-clinical models involves studies on a number of different therapeutic entities, including ghrelin, selective androgen receptor modulators (SARMs), as well as drugs targeting myostatin or melanocortin-4. In the human setting, studies using enobosarm (a SARM) and anamorelin (ghrelin) are in phase III. The last 3 years have seen significant efforts to define the field using consensus statements. In the future, these definitions should also be considered for guidelines and treatment trials in cardiovascular medicine. The current review aims to summarize important information and development in the fields of muscle wasting, sarcopenia and cachexia, focusing on findings in cardiovascular research, in order for cardiologists to have a better understanding of the progress in this still insufficiently known field.

Original languageEnglish
Pages (from-to)166-171
Number of pages6
JournalArchives of Medical Science
Volume9
Issue number1
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Cachexia
  • Cardiovascular illness
  • Heart failure
  • Mechanism
  • Muscle wasting
  • Sarcopenia
  • Therapy

ASJC Scopus subject areas

  • Medicine(all)

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