Highly electroconductive multiwalled carbon nanotubes as potentially useful tools for modulating calcium balancing in biological environments

Annalucia Serafino, Anna Rita Togna, Giuseppina I. Togna, Antonella Lisi, Mario Ledda, Settimio Grimaldi, Julie Russier, Federica Andreola, Marc Monthioux, Francois Béguin, Massimo Marcaccio, Stefania Rapino, Francesco Paolucci, Silvana Fiorito

Research output: Contribution to journalArticlepeer-review

Abstract

Aiming to explore the mechanisms modulating cell-carbon nanotube interactions, we investigated whether Ca 2+ ion balancing between intra- and extracellular environments could be affected by multiwalled carbon nanotubes (MWCNTs). We analyzed the effects induced by two different kinds of MWCNTs (as prepared and annealed at 2400°C) on the intracellular Ca 2+ ion levels in rat electrically sensitive cells and on the intercellular junction integrity of rat adenocarcinoma colon cells and platelet aggregation ability, which depend on the Ca 2+ concentration in the medium. MWCNTs, purified by annealing and more electroconductive as compared to nonannealed MWCNTs, affected Ca 2+ ion balancing between extra- and intracellular environments and induced changes on Ca 2+ ion-dependent cellular junctions and platelet aggregation, behaving as the calcium chelator ethylene glycol tetraacetic acid. This could be due to the sorption of cationic Ca 2+ ions on CNTs surface because of the excess of negatively charged electrons on the aromatic units formed on MWCNTs after annealing. From the Clinical Editor: The authors investigated whether Ca 2+ ion balance between intra- and extracellular space can be modulated by multiwalled carbon nanotubes (MWCNTs). Annealed nanotubes induced changes on Ca 2+ dependent cellular junctions and platelet aggregation, behaving similary to ethylene glycol tetraacetic acid, an established calcium chelator.

Original languageEnglish
Pages (from-to)299-307
Number of pages9
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume8
Issue number3
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Calcium balancing
  • Carbon nanotubes
  • Intracellular Ca mobilization
  • MWCNTs

ASJC Scopus subject areas

  • Molecular Medicine
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Medicine (miscellaneous)
  • Pharmaceutical Science

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