Highly focal BOLD activation on functional MRI in a patient with progressive myoclonic epilepsy and diffuse giant somatosensory evoked potentials

Paolo Manganotti, Francesco Brigo, Giada Zoccatelli, Franco Alessandrini, Francesca Benedetta Pizzini, Alberto Beltramello, Silvia Storti, Emanuela Formaggio, Antonio Fiaschi, Luigi Giuseppe Bongiovanni

Research output: Contribution to journalArticle

Abstract

We analyzed the effect of afferent input on patterns of brain electrical activation in a 31-year-old man with progressive myoclonic epilepsy (PME) by measuring the somatosensory evoked potential (SSEP) amplitude at the scalp after median nerve stimulation and examining the changes in the functional magnetic resonance imaging blood oxygen level-dependent (fMRI BOLD) signal. High-amplitude SSEPs were elicited at the wrist in association with highly focal BOLD activation of the contralateral sensorimotor areas. By contrast, no diffuse activation of either the frontal or the posterior parietal cortical areas was observed, as seen in previously recorded data on SSEPs from a healthy control group. The highly focal BOLD activation in this patient suggests that cortex hyperexcitability might be limited to the sensorimotor cortex in PME. The combined EEG-fMRI findings highlight a dissociation between BOLD activation and neurophysiological findings.

Original languageEnglish
Pages (from-to)579-582
Number of pages4
JournalEpilepsy and Behavior
Volume20
Issue number3
DOIs
Publication statusPublished - Mar 2011

Keywords

  • Functional magnetic resonance imaging
  • Progressive myoclonic epilepsy
  • Somatosensory evoked potentials

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

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    Manganotti, P., Brigo, F., Zoccatelli, G., Alessandrini, F., Pizzini, F. B., Beltramello, A., Storti, S., Formaggio, E., Fiaschi, A., & Bongiovanni, L. G. (2011). Highly focal BOLD activation on functional MRI in a patient with progressive myoclonic epilepsy and diffuse giant somatosensory evoked potentials. Epilepsy and Behavior, 20(3), 579-582. https://doi.org/10.1016/j.yebeh.2011.01.011