TY - JOUR
T1 - Highly focal BOLD activation on functional MRI in a patient with progressive myoclonic epilepsy and diffuse giant somatosensory evoked potentials
AU - Manganotti, Paolo
AU - Brigo, Francesco
AU - Zoccatelli, Giada
AU - Alessandrini, Franco
AU - Pizzini, Francesca Benedetta
AU - Beltramello, Alberto
AU - Storti, Silvia
AU - Formaggio, Emanuela
AU - Fiaschi, Antonio
AU - Bongiovanni, Luigi Giuseppe
PY - 2011/3
Y1 - 2011/3
N2 - We analyzed the effect of afferent input on patterns of brain electrical activation in a 31-year-old man with progressive myoclonic epilepsy (PME) by measuring the somatosensory evoked potential (SSEP) amplitude at the scalp after median nerve stimulation and examining the changes in the functional magnetic resonance imaging blood oxygen level-dependent (fMRI BOLD) signal. High-amplitude SSEPs were elicited at the wrist in association with highly focal BOLD activation of the contralateral sensorimotor areas. By contrast, no diffuse activation of either the frontal or the posterior parietal cortical areas was observed, as seen in previously recorded data on SSEPs from a healthy control group. The highly focal BOLD activation in this patient suggests that cortex hyperexcitability might be limited to the sensorimotor cortex in PME. The combined EEG-fMRI findings highlight a dissociation between BOLD activation and neurophysiological findings.
AB - We analyzed the effect of afferent input on patterns of brain electrical activation in a 31-year-old man with progressive myoclonic epilepsy (PME) by measuring the somatosensory evoked potential (SSEP) amplitude at the scalp after median nerve stimulation and examining the changes in the functional magnetic resonance imaging blood oxygen level-dependent (fMRI BOLD) signal. High-amplitude SSEPs were elicited at the wrist in association with highly focal BOLD activation of the contralateral sensorimotor areas. By contrast, no diffuse activation of either the frontal or the posterior parietal cortical areas was observed, as seen in previously recorded data on SSEPs from a healthy control group. The highly focal BOLD activation in this patient suggests that cortex hyperexcitability might be limited to the sensorimotor cortex in PME. The combined EEG-fMRI findings highlight a dissociation between BOLD activation and neurophysiological findings.
KW - Functional magnetic resonance imaging
KW - Progressive myoclonic epilepsy
KW - Somatosensory evoked potentials
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U2 - 10.1016/j.yebeh.2011.01.011
DO - 10.1016/j.yebeh.2011.01.011
M3 - Article
C2 - 21339087
AN - SCOPUS:79952734970
VL - 20
SP - 579
EP - 582
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
SN - 1525-5050
IS - 3
ER -