HindIII(+/-) polymorphism of the Y chromosome, blood pressure, and serum lipids: No evidence of association in three white populations

Paola Russo, Antonella Venezia, Fabio Lauria, Pasquale Strazzullo, Francesco P. Cappuccio, Licia Iacoviello, Gianvincenzo Barba, Alfonso Siani

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Male sex is associated with elevated levels of cardiovascular risk factors, including higher blood pressure (BP). Genetic variants on the Y chromosome may contribute to explain the sexual dimorphism in cardiovascular diseases. Among them, the HindIII(+/-) polymorphism of the male-specific region of the Y chromosome has been associated with BP and serum cholesterol levels, with conflicting results. We evaluated the association between the HindIII(+/-) polymorphism, prevalence of hypertension, BP, and serum lipid levels in a large sample of white men and the previously reported epistatic interaction between HindIII(+/-) and the -344C/T polymorphism of the aldosterone synthase gene (CYP11B2) on BP. Methods: From three European populations (UK n = 422; Belgium n = 313; Italy n = 1248) 1983 white men were phenotyped for BP and serum lipids and genotyped for HindIII(+/-) site and for -344C/T polymorphism in the promoter of CYP11B2 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: A higher frequency of the HindIII (+) was found in Italians (63%) as compared to both British (31%) and Belgians (28%) (P <.0001). We found no evidence of association of the HindIII(+/-) site with prevalence of hypertension, BP, and serum lipids in any of the three European populations examined and in the entire sample. Finally, we did not observe any interaction between the HindIII(+/-) polymorphism and the -344C/T variant of CYP11B2 on BP. Conclusions: Our data do not support the hypothesis that the HindIII(+/-) site of the Y chromosome is a marker of cardiovascular risk in white men, highlighting the need for replication in genetic association studies.

Original languageEnglish
Pages (from-to)331-338
Number of pages8
JournalAmerican Journal of Hypertension
Volume19
Issue number4
DOIs
Publication statusPublished - Apr 2006

Fingerprint

Y Chromosome
Cytochrome P-450 CYP11B2
Blood Pressure
Lipids
Serum
Population
Hypertension
Belgium
Genetic Association Studies
Sex Characteristics
Restriction Fragment Length Polymorphisms
Italy
Cardiovascular Diseases
Cholesterol
Polymerase Chain Reaction
Genes

Keywords

  • Blood pressure
  • Cardiovascular diseases
  • Genetic association
  • Lipids
  • Y chromosome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

HindIII(+/-) polymorphism of the Y chromosome, blood pressure, and serum lipids : No evidence of association in three white populations. / Russo, Paola; Venezia, Antonella; Lauria, Fabio; Strazzullo, Pasquale; Cappuccio, Francesco P.; Iacoviello, Licia; Barba, Gianvincenzo; Siani, Alfonso.

In: American Journal of Hypertension, Vol. 19, No. 4, 04.2006, p. 331-338.

Research output: Contribution to journalArticle

Russo, Paola ; Venezia, Antonella ; Lauria, Fabio ; Strazzullo, Pasquale ; Cappuccio, Francesco P. ; Iacoviello, Licia ; Barba, Gianvincenzo ; Siani, Alfonso. / HindIII(+/-) polymorphism of the Y chromosome, blood pressure, and serum lipids : No evidence of association in three white populations. In: American Journal of Hypertension. 2006 ; Vol. 19, No. 4. pp. 331-338.
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abstract = "Background: Male sex is associated with elevated levels of cardiovascular risk factors, including higher blood pressure (BP). Genetic variants on the Y chromosome may contribute to explain the sexual dimorphism in cardiovascular diseases. Among them, the HindIII(+/-) polymorphism of the male-specific region of the Y chromosome has been associated with BP and serum cholesterol levels, with conflicting results. We evaluated the association between the HindIII(+/-) polymorphism, prevalence of hypertension, BP, and serum lipid levels in a large sample of white men and the previously reported epistatic interaction between HindIII(+/-) and the -344C/T polymorphism of the aldosterone synthase gene (CYP11B2) on BP. Methods: From three European populations (UK n = 422; Belgium n = 313; Italy n = 1248) 1983 white men were phenotyped for BP and serum lipids and genotyped for HindIII(+/-) site and for -344C/T polymorphism in the promoter of CYP11B2 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: A higher frequency of the HindIII (+) was found in Italians (63{\%}) as compared to both British (31{\%}) and Belgians (28{\%}) (P <.0001). We found no evidence of association of the HindIII(+/-) site with prevalence of hypertension, BP, and serum lipids in any of the three European populations examined and in the entire sample. Finally, we did not observe any interaction between the HindIII(+/-) polymorphism and the -344C/T variant of CYP11B2 on BP. Conclusions: Our data do not support the hypothesis that the HindIII(+/-) site of the Y chromosome is a marker of cardiovascular risk in white men, highlighting the need for replication in genetic association studies.",
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T1 - HindIII(+/-) polymorphism of the Y chromosome, blood pressure, and serum lipids

T2 - No evidence of association in three white populations

AU - Russo, Paola

AU - Venezia, Antonella

AU - Lauria, Fabio

AU - Strazzullo, Pasquale

AU - Cappuccio, Francesco P.

AU - Iacoviello, Licia

AU - Barba, Gianvincenzo

AU - Siani, Alfonso

PY - 2006/4

Y1 - 2006/4

N2 - Background: Male sex is associated with elevated levels of cardiovascular risk factors, including higher blood pressure (BP). Genetic variants on the Y chromosome may contribute to explain the sexual dimorphism in cardiovascular diseases. Among them, the HindIII(+/-) polymorphism of the male-specific region of the Y chromosome has been associated with BP and serum cholesterol levels, with conflicting results. We evaluated the association between the HindIII(+/-) polymorphism, prevalence of hypertension, BP, and serum lipid levels in a large sample of white men and the previously reported epistatic interaction between HindIII(+/-) and the -344C/T polymorphism of the aldosterone synthase gene (CYP11B2) on BP. Methods: From three European populations (UK n = 422; Belgium n = 313; Italy n = 1248) 1983 white men were phenotyped for BP and serum lipids and genotyped for HindIII(+/-) site and for -344C/T polymorphism in the promoter of CYP11B2 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: A higher frequency of the HindIII (+) was found in Italians (63%) as compared to both British (31%) and Belgians (28%) (P <.0001). We found no evidence of association of the HindIII(+/-) site with prevalence of hypertension, BP, and serum lipids in any of the three European populations examined and in the entire sample. Finally, we did not observe any interaction between the HindIII(+/-) polymorphism and the -344C/T variant of CYP11B2 on BP. Conclusions: Our data do not support the hypothesis that the HindIII(+/-) site of the Y chromosome is a marker of cardiovascular risk in white men, highlighting the need for replication in genetic association studies.

AB - Background: Male sex is associated with elevated levels of cardiovascular risk factors, including higher blood pressure (BP). Genetic variants on the Y chromosome may contribute to explain the sexual dimorphism in cardiovascular diseases. Among them, the HindIII(+/-) polymorphism of the male-specific region of the Y chromosome has been associated with BP and serum cholesterol levels, with conflicting results. We evaluated the association between the HindIII(+/-) polymorphism, prevalence of hypertension, BP, and serum lipid levels in a large sample of white men and the previously reported epistatic interaction between HindIII(+/-) and the -344C/T polymorphism of the aldosterone synthase gene (CYP11B2) on BP. Methods: From three European populations (UK n = 422; Belgium n = 313; Italy n = 1248) 1983 white men were phenotyped for BP and serum lipids and genotyped for HindIII(+/-) site and for -344C/T polymorphism in the promoter of CYP11B2 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: A higher frequency of the HindIII (+) was found in Italians (63%) as compared to both British (31%) and Belgians (28%) (P <.0001). We found no evidence of association of the HindIII(+/-) site with prevalence of hypertension, BP, and serum lipids in any of the three European populations examined and in the entire sample. Finally, we did not observe any interaction between the HindIII(+/-) polymorphism and the -344C/T variant of CYP11B2 on BP. Conclusions: Our data do not support the hypothesis that the HindIII(+/-) site of the Y chromosome is a marker of cardiovascular risk in white men, highlighting the need for replication in genetic association studies.

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