Abstract
Background: Male sex is associated with elevated levels of cardiovascular risk factors, including higher blood pressure (BP). Genetic variants on the Y chromosome may contribute to explain the sexual dimorphism in cardiovascular diseases. Among them, the HindIII(+/-) polymorphism of the male-specific region of the Y chromosome has been associated with BP and serum cholesterol levels, with conflicting results. We evaluated the association between the HindIII(+/-) polymorphism, prevalence of hypertension, BP, and serum lipid levels in a large sample of white men and the previously reported epistatic interaction between HindIII(+/-) and the -344C/T polymorphism of the aldosterone synthase gene (CYP11B2) on BP. Methods: From three European populations (UK n = 422; Belgium n = 313; Italy n = 1248) 1983 white men were phenotyped for BP and serum lipids and genotyped for HindIII(+/-) site and for -344C/T polymorphism in the promoter of CYP11B2 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: A higher frequency of the HindIII (+) was found in Italians (63%) as compared to both British (31%) and Belgians (28%) (P <.0001). We found no evidence of association of the HindIII(+/-) site with prevalence of hypertension, BP, and serum lipids in any of the three European populations examined and in the entire sample. Finally, we did not observe any interaction between the HindIII(+/-) polymorphism and the -344C/T variant of CYP11B2 on BP. Conclusions: Our data do not support the hypothesis that the HindIII(+/-) site of the Y chromosome is a marker of cardiovascular risk in white men, highlighting the need for replication in genetic association studies.
| Original language | English |
|---|---|
| Pages (from-to) | 331-338 |
| Number of pages | 8 |
| Journal | American Journal of Hypertension |
| Volume | 19 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2006 |
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Keywords
- Blood pressure
- Cardiovascular diseases
- Genetic association
- Lipids
- Y chromosome
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
HindIII(+/-) polymorphism of the Y chromosome, blood pressure, and serum lipids : No evidence of association in three white populations. / Russo, Paola; Venezia, Antonella; Lauria, Fabio; Strazzullo, Pasquale; Cappuccio, Francesco P.; Iacoviello, Licia; Barba, Gianvincenzo; Siani, Alfonso.
In: American Journal of Hypertension, Vol. 19, No. 4, 04.2006, p. 331-338.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HindIII(+/-) polymorphism of the Y chromosome, blood pressure, and serum lipids
T2 - No evidence of association in three white populations
AU - Russo, Paola
AU - Venezia, Antonella
AU - Lauria, Fabio
AU - Strazzullo, Pasquale
AU - Cappuccio, Francesco P.
AU - Iacoviello, Licia
AU - Barba, Gianvincenzo
AU - Siani, Alfonso
PY - 2006/4
Y1 - 2006/4
N2 - Background: Male sex is associated with elevated levels of cardiovascular risk factors, including higher blood pressure (BP). Genetic variants on the Y chromosome may contribute to explain the sexual dimorphism in cardiovascular diseases. Among them, the HindIII(+/-) polymorphism of the male-specific region of the Y chromosome has been associated with BP and serum cholesterol levels, with conflicting results. We evaluated the association between the HindIII(+/-) polymorphism, prevalence of hypertension, BP, and serum lipid levels in a large sample of white men and the previously reported epistatic interaction between HindIII(+/-) and the -344C/T polymorphism of the aldosterone synthase gene (CYP11B2) on BP. Methods: From three European populations (UK n = 422; Belgium n = 313; Italy n = 1248) 1983 white men were phenotyped for BP and serum lipids and genotyped for HindIII(+/-) site and for -344C/T polymorphism in the promoter of CYP11B2 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: A higher frequency of the HindIII (+) was found in Italians (63%) as compared to both British (31%) and Belgians (28%) (P <.0001). We found no evidence of association of the HindIII(+/-) site with prevalence of hypertension, BP, and serum lipids in any of the three European populations examined and in the entire sample. Finally, we did not observe any interaction between the HindIII(+/-) polymorphism and the -344C/T variant of CYP11B2 on BP. Conclusions: Our data do not support the hypothesis that the HindIII(+/-) site of the Y chromosome is a marker of cardiovascular risk in white men, highlighting the need for replication in genetic association studies.
AB - Background: Male sex is associated with elevated levels of cardiovascular risk factors, including higher blood pressure (BP). Genetic variants on the Y chromosome may contribute to explain the sexual dimorphism in cardiovascular diseases. Among them, the HindIII(+/-) polymorphism of the male-specific region of the Y chromosome has been associated with BP and serum cholesterol levels, with conflicting results. We evaluated the association between the HindIII(+/-) polymorphism, prevalence of hypertension, BP, and serum lipid levels in a large sample of white men and the previously reported epistatic interaction between HindIII(+/-) and the -344C/T polymorphism of the aldosterone synthase gene (CYP11B2) on BP. Methods: From three European populations (UK n = 422; Belgium n = 313; Italy n = 1248) 1983 white men were phenotyped for BP and serum lipids and genotyped for HindIII(+/-) site and for -344C/T polymorphism in the promoter of CYP11B2 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: A higher frequency of the HindIII (+) was found in Italians (63%) as compared to both British (31%) and Belgians (28%) (P <.0001). We found no evidence of association of the HindIII(+/-) site with prevalence of hypertension, BP, and serum lipids in any of the three European populations examined and in the entire sample. Finally, we did not observe any interaction between the HindIII(+/-) polymorphism and the -344C/T variant of CYP11B2 on BP. Conclusions: Our data do not support the hypothesis that the HindIII(+/-) site of the Y chromosome is a marker of cardiovascular risk in white men, highlighting the need for replication in genetic association studies.
KW - Blood pressure
KW - Cardiovascular diseases
KW - Genetic association
KW - Lipids
KW - Y chromosome
UR - http://www.scopus.com/inward/record.url?scp=33645370756&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645370756&partnerID=8YFLogxK
U2 - 10.1016/j.amjhyper.2005.10.003
DO - 10.1016/j.amjhyper.2005.10.003
M3 - Article
C2 - 16580565
AN - SCOPUS:33645370756
VL - 19
SP - 331
EP - 338
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 4
ER -