Hints on transcriptional control of essential players in heterotopic ossification of Fibrodysplasia Ossificans Progressiva

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Signaling of the Bone Morphogenetic Protein (BMP) pathway is influenced by the level of expression of its components, in particular receptors, intracellular molecules and target genes which largely depends on gene transcription. One peculiar aspect of Fibrodysplasia Ossificans Progressiva (FOP) relates to the cell types in which the genetic mutation exerts its effects, then not only those involved in the heterotopic ossification processes but also others that participate in the inflammatory phases preceding and triggering heterotopic ossification. Such effects are in part detectable as variation in gene expression, which is also variably manifesting in term of time of appearance in different phases of the inflammatory or ossification processes.

Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalBone
Volume109
DOIs
Publication statusPublished - Apr 1 2018

Fingerprint

Myositis Ossificans
Heterotopic Ossification
Bone Morphogenetic Proteins
Osteogenesis
Genes
Gene Expression
Mutation

Keywords

  • Activin
  • ACVR1/Alk2
  • BMP
  • Fibrodysplasia Ossificans Progressiva (FOP)
  • Follistatin
  • Heterotopic ossification
  • Smad
  • Transcriptional regulation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

Cite this

Hints on transcriptional control of essential players in heterotopic ossification of Fibrodysplasia Ossificans Progressiva. / Ravazzolo, Roberto; Cappato, Serena; Bocciardi, Renata.

In: Bone, Vol. 109, 01.04.2018, p. 187-191.

Research output: Contribution to journalReview article

@article{c751d8589dcb4a5a9767034b92203681,
title = "Hints on transcriptional control of essential players in heterotopic ossification of Fibrodysplasia Ossificans Progressiva",
abstract = "Signaling of the Bone Morphogenetic Protein (BMP) pathway is influenced by the level of expression of its components, in particular receptors, intracellular molecules and target genes which largely depends on gene transcription. One peculiar aspect of Fibrodysplasia Ossificans Progressiva (FOP) relates to the cell types in which the genetic mutation exerts its effects, then not only those involved in the heterotopic ossification processes but also others that participate in the inflammatory phases preceding and triggering heterotopic ossification. Such effects are in part detectable as variation in gene expression, which is also variably manifesting in term of time of appearance in different phases of the inflammatory or ossification processes.",
keywords = "Activin, ACVR1/Alk2, BMP, Fibrodysplasia Ossificans Progressiva (FOP), Follistatin, Heterotopic ossification, Smad, Transcriptional regulation",
author = "Roberto Ravazzolo and Serena Cappato and Renata Bocciardi",
year = "2018",
month = "4",
day = "1",
doi = "10.1016/j.bone.2017.10.028",
language = "English",
volume = "109",
pages = "187--191",
journal = "Bone",
issn = "8756-3282",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Hints on transcriptional control of essential players in heterotopic ossification of Fibrodysplasia Ossificans Progressiva

AU - Ravazzolo, Roberto

AU - Cappato, Serena

AU - Bocciardi, Renata

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Signaling of the Bone Morphogenetic Protein (BMP) pathway is influenced by the level of expression of its components, in particular receptors, intracellular molecules and target genes which largely depends on gene transcription. One peculiar aspect of Fibrodysplasia Ossificans Progressiva (FOP) relates to the cell types in which the genetic mutation exerts its effects, then not only those involved in the heterotopic ossification processes but also others that participate in the inflammatory phases preceding and triggering heterotopic ossification. Such effects are in part detectable as variation in gene expression, which is also variably manifesting in term of time of appearance in different phases of the inflammatory or ossification processes.

AB - Signaling of the Bone Morphogenetic Protein (BMP) pathway is influenced by the level of expression of its components, in particular receptors, intracellular molecules and target genes which largely depends on gene transcription. One peculiar aspect of Fibrodysplasia Ossificans Progressiva (FOP) relates to the cell types in which the genetic mutation exerts its effects, then not only those involved in the heterotopic ossification processes but also others that participate in the inflammatory phases preceding and triggering heterotopic ossification. Such effects are in part detectable as variation in gene expression, which is also variably manifesting in term of time of appearance in different phases of the inflammatory or ossification processes.

KW - Activin

KW - ACVR1/Alk2

KW - BMP

KW - Fibrodysplasia Ossificans Progressiva (FOP)

KW - Follistatin

KW - Heterotopic ossification

KW - Smad

KW - Transcriptional regulation

UR - http://www.scopus.com/inward/record.url?scp=85034416105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034416105&partnerID=8YFLogxK

U2 - 10.1016/j.bone.2017.10.028

DO - 10.1016/j.bone.2017.10.028

M3 - Review article

C2 - 29100956

AN - SCOPUS:85034416105

VL - 109

SP - 187

EP - 191

JO - Bone

JF - Bone

SN - 8756-3282

ER -