HIPK2: A multitalented partner for transcription factors in DNA damage response and development

Cinzia Rinaldo; Andrea Prodosmo; Francesca Siepi; Silvia Soddu

doi:10.1139/O07-071

HIPK2: A multitalented partner for transcription factors in DNA damage response and development

Cinzia Rinaldo, Andrea Prodosmo, Francesca Siepi, Silvia Soddu

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

Protein phosphorylation is a widely diffuse and versatile post-translational modification that controls many cellular processes, from signal transduction to gene transcription. The homeodomain-interacting protein kinases (HIPKs) belong to a new family of serine-threonine kinases first identified as corepressors for homeodomain transcription factors. Different screenings for the identification of new partners of transcription factors have indicated that HIPK2, the best characterized member of the HIPK family, is a multitalented coregulator of an increasing number of transcription factors and cofactors. The aim of this review is to describe the different mechanisms through which HIPK2 regulates gene transcription.

Original language	English
Pages (from-to)	411-418
Number of pages	8
Journal	Biochemistry and Cell Biology
Volume	85
Issue number	4
DOIs	https://doi.org/10.1139/O07-071
Publication status	Published - Aug 2007

Keywords

Apoptosis
HIPK2
p53
Phosphorylation
Transcription

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Biochemistry
Cell Biology

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10.1139/O07-071

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abstract = "Protein phosphorylation is a widely diffuse and versatile post-translational modification that controls many cellular processes, from signal transduction to gene transcription. The homeodomain-interacting protein kinases (HIPKs) belong to a new family of serine-threonine kinases first identified as corepressors for homeodomain transcription factors. Different screenings for the identification of new partners of transcription factors have indicated that HIPK2, the best characterized member of the HIPK family, is a multitalented coregulator of an increasing number of transcription factors and cofactors. The aim of this review is to describe the different mechanisms through which HIPK2 regulates gene transcription.",

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AU - Rinaldo, Cinzia

AU - Prodosmo, Andrea

AU - Siepi, Francesca

AU - Soddu, Silvia

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AB - Protein phosphorylation is a widely diffuse and versatile post-translational modification that controls many cellular processes, from signal transduction to gene transcription. The homeodomain-interacting protein kinases (HIPKs) belong to a new family of serine-threonine kinases first identified as corepressors for homeodomain transcription factors. Different screenings for the identification of new partners of transcription factors have indicated that HIPK2, the best characterized member of the HIPK family, is a multitalented coregulator of an increasing number of transcription factors and cofactors. The aim of this review is to describe the different mechanisms through which HIPK2 regulates gene transcription.

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HIPK2: A multitalented partner for transcription factors in DNA damage response and development

Abstract

Keywords

ASJC Scopus subject areas

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