Abstract
Over the past decade several investigators have reported on the physical interaction of serine/threonine kinases of the homeodomain interacting-protein family (HIPKs) with increasing number of nuclear factors and on their localization in different nuclear sub-compartments. Although we are still far from a global understanding of the molecular consequences of HIPK subnuclear compartmentalization, the spatial description of particular interactions and posttranslational modifications promoted by these kinases on key cellular regulators might provide relevant insights. Here we will discuss the possible implications of the HIPK subnuclear localization in the regulation of gene transcription and in the cell response to stress.
Original language | English |
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Pages (from-to) | 2124-2129 |
Number of pages | 6 |
Journal | Biochimica et Biophysica Acta - Molecular Cell Research |
Volume | 1783 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2008 |
Keywords
- DNA-damage response
- HIPK
- HIPK domain
- p53
- Pc2
- PML-body
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology