HIPKs: Jack of all trades in basic nuclear activities

Cinzia Rinaldo, Francesca Siepi, Andrea Prodosmo, Silvia Soddu

Research output: Contribution to journalArticle

Abstract

Over the past decade several investigators have reported on the physical interaction of serine/threonine kinases of the homeodomain interacting-protein family (HIPKs) with increasing number of nuclear factors and on their localization in different nuclear sub-compartments. Although we are still far from a global understanding of the molecular consequences of HIPK subnuclear compartmentalization, the spatial description of particular interactions and posttranslational modifications promoted by these kinases on key cellular regulators might provide relevant insights. Here we will discuss the possible implications of the HIPK subnuclear localization in the regulation of gene transcription and in the cell response to stress.

Original languageEnglish
Pages (from-to)2124-2129
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1783
Issue number11
DOIs
Publication statusPublished - Nov 2008

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Keywords

  • DNA-damage response
  • HIPK
  • HIPK domain
  • p53
  • Pc2
  • PML-body

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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