Hippocampal-DMN disconnectivity in MS is related to WM lesions and depression

Maria A. Rocca, Emanuele Pravatà, Paola Valsasina, Marta Radaelli, Bruno Colombo, Laura Vacchi, Claudio Gobbi, Giancarlo Comi, Andrea Falini, Massimo Filippi

Research output: Contribution to journalArticlepeer-review


The hippocampus is part of the default-mode network (DMN) and is functionally hit early in multiple sclerosis (MS). Hippocampal and DMN dysfunctions have been associated with depression, both in patients with MS and in major depressive disorders. We hypothesized that white matter lesions may contribute, through a disconnection mechanism, to hippocampal dysfunction. To test this, we assessed the relationship between hippocampal resting-state (RS) functional connectivity (FC) abnormalities with brain T2 lesion volumes and the presence and severity of depression. Structural and RS fMRI images were acquired from 69 patients with cognitively intact MS and 42 matched healthy controls (HC). Depression was quantified using the Montgomery-Asberg Depression Rating Scale. Seed-voxel hippocampal RS FC was assessed. SPM8 was used for between-group comparisons and correlation analysis between RS FC abnormalities with clinical and structural MRI variables. Compared to HC, patients with MS showed a significant atrophy of the whole brain and left hippocampus (P

Original languageEnglish
Pages (from-to)5051-5063
Number of pages13
JournalHuman Brain Mapping
Issue number12
Publication statusPublished - Dec 1 2015


  • Default-mode network
  • Depression
  • Hippocampus
  • Multiple sclerosis
  • Resting-state fMRI
  • WM lesions

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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