Abstract
Background: Alterations in hippocampal structure and function are present in bipolar disorder (BD). Childhood trauma is associated with risk for BD, and the several subfields of the hippocampus are differentially sensitive to the effects of stressors of the sort associated with risk for BD. The current study therefore sought to test the hypothesis that childhood trauma may be differentially associated with abnormal hippocampal subfield volumes in BD. Methods: 104 participants with BD type I (BD-I, n = 56) or BD type II (BD-II, n = 48) and 81 healthy controls (HC) underwent high-resolution structural magnetic resonance neuroimaging. Hippocampal subfield volumes were determined using FreeSurfer. Childhood trauma was assessed with the Childhood Trauma Questionnaire (CTQ). Results: There were significant effects of diagnosis on intracranial volume corrected hippocampal subfield volumes bilaterally as well as a significant interaction between diagnosis and childhood trauma. Hippocampal volumes did not differ between the BD-I and BD-II subgroups but hippocampal volumes were smaller in both groups when compared to HC. There was a significant effect of childhood trauma on bilateral presubiculum volume as well as significant interactions between diagnosis and childhood trauma on bilateral CA1, presubiculum and subiculum volumes, the direction of which differed between individuals with BD (larger) and HC (smaller). Limitations: Recall bias may influence the reliability of the retrospective assessment of childhood trauma experiences. Conclusions: Childhood trauma demonstrates differential effects on hippocampal subfield volumes of BD and HC, particularly in hippocampal subfields involved in emotion regulation.
| Original language | English |
|---|---|
| Pages (from-to) | 35-43 |
| Number of pages | 9 |
| Journal | Journal of Affective Disorders |
| Volume | 253 |
| DOIs | |
| Publication status | Published - Jun 15 2019 |
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Keywords
- Bipolar disorders
- Childhood trauma
- Hippocampal subfields
- Hippocampus
- Neuroimaging
ASJC Scopus subject areas
- Clinical Psychology
- Psychiatry and Mental health
Cite this
Hippocampal subfield volumes and childhood trauma in bipolar disorders. / Janiri, Delfina; Sani, Gabriele; De Rossi, Pietro; Piras, Fabrizio; Banaj, Nerisa; Ciullo, Valentina; Simonetti, Alessio; Arciniegas, David B.; Spalletta, Gianfranco.
In: Journal of Affective Disorders, Vol. 253, 15.06.2019, p. 35-43.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hippocampal subfield volumes and childhood trauma in bipolar disorders
AU - Janiri, Delfina
AU - Sani, Gabriele
AU - De Rossi, Pietro
AU - Piras, Fabrizio
AU - Banaj, Nerisa
AU - Ciullo, Valentina
AU - Simonetti, Alessio
AU - Arciniegas, David B.
AU - Spalletta, Gianfranco
PY - 2019/6/15
Y1 - 2019/6/15
N2 - Background: Alterations in hippocampal structure and function are present in bipolar disorder (BD). Childhood trauma is associated with risk for BD, and the several subfields of the hippocampus are differentially sensitive to the effects of stressors of the sort associated with risk for BD. The current study therefore sought to test the hypothesis that childhood trauma may be differentially associated with abnormal hippocampal subfield volumes in BD. Methods: 104 participants with BD type I (BD-I, n = 56) or BD type II (BD-II, n = 48) and 81 healthy controls (HC) underwent high-resolution structural magnetic resonance neuroimaging. Hippocampal subfield volumes were determined using FreeSurfer. Childhood trauma was assessed with the Childhood Trauma Questionnaire (CTQ). Results: There were significant effects of diagnosis on intracranial volume corrected hippocampal subfield volumes bilaterally as well as a significant interaction between diagnosis and childhood trauma. Hippocampal volumes did not differ between the BD-I and BD-II subgroups but hippocampal volumes were smaller in both groups when compared to HC. There was a significant effect of childhood trauma on bilateral presubiculum volume as well as significant interactions between diagnosis and childhood trauma on bilateral CA1, presubiculum and subiculum volumes, the direction of which differed between individuals with BD (larger) and HC (smaller). Limitations: Recall bias may influence the reliability of the retrospective assessment of childhood trauma experiences. Conclusions: Childhood trauma demonstrates differential effects on hippocampal subfield volumes of BD and HC, particularly in hippocampal subfields involved in emotion regulation.
AB - Background: Alterations in hippocampal structure and function are present in bipolar disorder (BD). Childhood trauma is associated with risk for BD, and the several subfields of the hippocampus are differentially sensitive to the effects of stressors of the sort associated with risk for BD. The current study therefore sought to test the hypothesis that childhood trauma may be differentially associated with abnormal hippocampal subfield volumes in BD. Methods: 104 participants with BD type I (BD-I, n = 56) or BD type II (BD-II, n = 48) and 81 healthy controls (HC) underwent high-resolution structural magnetic resonance neuroimaging. Hippocampal subfield volumes were determined using FreeSurfer. Childhood trauma was assessed with the Childhood Trauma Questionnaire (CTQ). Results: There were significant effects of diagnosis on intracranial volume corrected hippocampal subfield volumes bilaterally as well as a significant interaction between diagnosis and childhood trauma. Hippocampal volumes did not differ between the BD-I and BD-II subgroups but hippocampal volumes were smaller in both groups when compared to HC. There was a significant effect of childhood trauma on bilateral presubiculum volume as well as significant interactions between diagnosis and childhood trauma on bilateral CA1, presubiculum and subiculum volumes, the direction of which differed between individuals with BD (larger) and HC (smaller). Limitations: Recall bias may influence the reliability of the retrospective assessment of childhood trauma experiences. Conclusions: Childhood trauma demonstrates differential effects on hippocampal subfield volumes of BD and HC, particularly in hippocampal subfields involved in emotion regulation.
KW - Bipolar disorders
KW - Childhood trauma
KW - Hippocampal subfields
KW - Hippocampus
KW - Neuroimaging
UR - http://www.scopus.com/inward/record.url?scp=85064495186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064495186&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2019.04.071
DO - 10.1016/j.jad.2019.04.071
M3 - Article
AN - SCOPUS:85064495186
VL - 253
SP - 35
EP - 43
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -