Hippocampal subfield volumes and childhood trauma in bipolar disorders

Delfina Janiri, Gabriele Sani, Pietro De Rossi, Fabrizio Piras, Nerisa Banaj, Valentina Ciullo, Alessio Simonetti, David B. Arciniegas, Gianfranco Spalletta

Research output: Contribution to journalArticle

Abstract

Background: Alterations in hippocampal structure and function are present in bipolar disorder (BD). Childhood trauma is associated with risk for BD, and the several subfields of the hippocampus are differentially sensitive to the effects of stressors of the sort associated with risk for BD. The current study therefore sought to test the hypothesis that childhood trauma may be differentially associated with abnormal hippocampal subfield volumes in BD. Methods: 104 participants with BD type I (BD-I, n = 56) or BD type II (BD-II, n = 48) and 81 healthy controls (HC) underwent high-resolution structural magnetic resonance neuroimaging. Hippocampal subfield volumes were determined using FreeSurfer. Childhood trauma was assessed with the Childhood Trauma Questionnaire (CTQ). Results: There were significant effects of diagnosis on intracranial volume corrected hippocampal subfield volumes bilaterally as well as a significant interaction between diagnosis and childhood trauma. Hippocampal volumes did not differ between the BD-I and BD-II subgroups but hippocampal volumes were smaller in both groups when compared to HC. There was a significant effect of childhood trauma on bilateral presubiculum volume as well as significant interactions between diagnosis and childhood trauma on bilateral CA1, presubiculum and subiculum volumes, the direction of which differed between individuals with BD (larger) and HC (smaller). Limitations: Recall bias may influence the reliability of the retrospective assessment of childhood trauma experiences. Conclusions: Childhood trauma demonstrates differential effects on hippocampal subfield volumes of BD and HC, particularly in hippocampal subfields involved in emotion regulation.

Original languageEnglish
Pages (from-to)35-43
Number of pages9
JournalJournal of Affective Disorders
Volume253
DOIs
Publication statusPublished - Jun 15 2019

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Bipolar Disorder
Wounds and Injuries
Parahippocampal Gyrus
Hippocampus
Neuroimaging
Emotions
Magnetic Resonance Spectroscopy

Keywords

  • Bipolar disorders
  • Childhood trauma
  • Hippocampal subfields
  • Hippocampus
  • Neuroimaging

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Hippocampal subfield volumes and childhood trauma in bipolar disorders. / Janiri, Delfina; Sani, Gabriele; De Rossi, Pietro; Piras, Fabrizio; Banaj, Nerisa; Ciullo, Valentina; Simonetti, Alessio; Arciniegas, David B.; Spalletta, Gianfranco.

In: Journal of Affective Disorders, Vol. 253, 15.06.2019, p. 35-43.

Research output: Contribution to journalArticle

Janiri, Delfina ; Sani, Gabriele ; De Rossi, Pietro ; Piras, Fabrizio ; Banaj, Nerisa ; Ciullo, Valentina ; Simonetti, Alessio ; Arciniegas, David B. ; Spalletta, Gianfranco. / Hippocampal subfield volumes and childhood trauma in bipolar disorders. In: Journal of Affective Disorders. 2019 ; Vol. 253. pp. 35-43.
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AU - Banaj, Nerisa

AU - Ciullo, Valentina

AU - Simonetti, Alessio

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AB - Background: Alterations in hippocampal structure and function are present in bipolar disorder (BD). Childhood trauma is associated with risk for BD, and the several subfields of the hippocampus are differentially sensitive to the effects of stressors of the sort associated with risk for BD. The current study therefore sought to test the hypothesis that childhood trauma may be differentially associated with abnormal hippocampal subfield volumes in BD. Methods: 104 participants with BD type I (BD-I, n = 56) or BD type II (BD-II, n = 48) and 81 healthy controls (HC) underwent high-resolution structural magnetic resonance neuroimaging. Hippocampal subfield volumes were determined using FreeSurfer. Childhood trauma was assessed with the Childhood Trauma Questionnaire (CTQ). Results: There were significant effects of diagnosis on intracranial volume corrected hippocampal subfield volumes bilaterally as well as a significant interaction between diagnosis and childhood trauma. Hippocampal volumes did not differ between the BD-I and BD-II subgroups but hippocampal volumes were smaller in both groups when compared to HC. There was a significant effect of childhood trauma on bilateral presubiculum volume as well as significant interactions between diagnosis and childhood trauma on bilateral CA1, presubiculum and subiculum volumes, the direction of which differed between individuals with BD (larger) and HC (smaller). Limitations: Recall bias may influence the reliability of the retrospective assessment of childhood trauma experiences. Conclusions: Childhood trauma demonstrates differential effects on hippocampal subfield volumes of BD and HC, particularly in hippocampal subfields involved in emotion regulation.

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