Hippocampal subfield volumes in short- and long-term lithium-treated patients with bipolar I disorder

Alessio Simonetti, Gabriele Sani, Claudia Dacquino, Fabrizio Piras, Pietro De Rossi, Carlo Caltagirone, William Coryell, Gianfranco Spalletta

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives: Patients diagnosed with bipolar disorder (BP) may experience hippocampal atrophy. Lithium exposure has been associated with increased hippocampal volumes. However, its effects on hippocampal subfields remain to be clarified. Methods: We investigated the effects of short- and long-term lithium exposure on the hippocampus and its subfields in patients affected by bipolar I disorder (BP-I). Hippocampal subfields and total hippocampal volumes were measured in 60 subjects divided into four groups: 15 patients with BP-I who were never exposed to lithium [no-exposure group (NE)], 15 patients with BP-I exposed to lithium for <24 months [short-exposure group (SE)], 15 patients with BP-I exposed to lithium for > 24 months [long-exposure group (LE)], and 15 healthy control subjects (HC). Results: The SE and NE groups showed smaller total hippocampal volumes and smaller bilateral cornu ammonis CA2-3, CA4-dentate gyrus (DG), presubiculum, and subiculum volumes compared with HC. The LE group showed larger total hippocampal volumes and bilateral CA2-3, left CA4-DG, left presubiculum, and right subiculum volumes compared with the NE group, and larger volumes of the right CA2-3, left CA4-DG, left presubiculum, and right subiculum compared with the SE group. No differences were found between the LE group and HC or between the SE and NE groups. Conclusions: Long-term, but not short-term, exposure to lithium treatment may exert neuroprotective effects on specific hippocampal subfields linked to disease progression.

Original languageEnglish
Pages (from-to)352-362
Number of pages11
JournalBipolar Disorders
Volume18
Issue number4
DOIs
Publication statusPublished - Jun 1 2016

Fingerprint

Bipolar Disorder
Lithium
Hippocampus
Parahippocampal Gyrus
Dentate Gyrus
Healthy Volunteers
Neuroprotective Agents
Atrophy
Disease Progression
Control Groups
Therapeutics

Keywords

  • bipolar disorder
  • hippocampal subfields
  • hippocampus
  • lithium
  • treatment

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Hippocampal subfield volumes in short- and long-term lithium-treated patients with bipolar I disorder. / Simonetti, Alessio; Sani, Gabriele; Dacquino, Claudia; Piras, Fabrizio; De Rossi, Pietro; Caltagirone, Carlo; Coryell, William; Spalletta, Gianfranco.

In: Bipolar Disorders, Vol. 18, No. 4, 01.06.2016, p. 352-362.

Research output: Contribution to journalArticle

Simonetti, Alessio ; Sani, Gabriele ; Dacquino, Claudia ; Piras, Fabrizio ; De Rossi, Pietro ; Caltagirone, Carlo ; Coryell, William ; Spalletta, Gianfranco. / Hippocampal subfield volumes in short- and long-term lithium-treated patients with bipolar I disorder. In: Bipolar Disorders. 2016 ; Vol. 18, No. 4. pp. 352-362.
@article{95c179618f4c4d01976387779442181c,
title = "Hippocampal subfield volumes in short- and long-term lithium-treated patients with bipolar I disorder",
abstract = "Objectives: Patients diagnosed with bipolar disorder (BP) may experience hippocampal atrophy. Lithium exposure has been associated with increased hippocampal volumes. However, its effects on hippocampal subfields remain to be clarified. Methods: We investigated the effects of short- and long-term lithium exposure on the hippocampus and its subfields in patients affected by bipolar I disorder (BP-I). Hippocampal subfields and total hippocampal volumes were measured in 60 subjects divided into four groups: 15 patients with BP-I who were never exposed to lithium [no-exposure group (NE)], 15 patients with BP-I exposed to lithium for <24 months [short-exposure group (SE)], 15 patients with BP-I exposed to lithium for > 24 months [long-exposure group (LE)], and 15 healthy control subjects (HC). Results: The SE and NE groups showed smaller total hippocampal volumes and smaller bilateral cornu ammonis CA2-3, CA4-dentate gyrus (DG), presubiculum, and subiculum volumes compared with HC. The LE group showed larger total hippocampal volumes and bilateral CA2-3, left CA4-DG, left presubiculum, and right subiculum volumes compared with the NE group, and larger volumes of the right CA2-3, left CA4-DG, left presubiculum, and right subiculum compared with the SE group. No differences were found between the LE group and HC or between the SE and NE groups. Conclusions: Long-term, but not short-term, exposure to lithium treatment may exert neuroprotective effects on specific hippocampal subfields linked to disease progression.",
keywords = "bipolar disorder, hippocampal subfields, hippocampus, lithium, treatment",
author = "Alessio Simonetti and Gabriele Sani and Claudia Dacquino and Fabrizio Piras and {De Rossi}, Pietro and Carlo Caltagirone and William Coryell and Gianfranco Spalletta",
year = "2016",
month = "6",
day = "1",
doi = "10.1111/bdi.12394",
language = "English",
volume = "18",
pages = "352--362",
journal = "Bipolar Disorders",
issn = "1398-5647",
publisher = "Blackwell Munksgaard",
number = "4",

}

TY - JOUR

T1 - Hippocampal subfield volumes in short- and long-term lithium-treated patients with bipolar I disorder

AU - Simonetti, Alessio

AU - Sani, Gabriele

AU - Dacquino, Claudia

AU - Piras, Fabrizio

AU - De Rossi, Pietro

AU - Caltagirone, Carlo

AU - Coryell, William

AU - Spalletta, Gianfranco

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Objectives: Patients diagnosed with bipolar disorder (BP) may experience hippocampal atrophy. Lithium exposure has been associated with increased hippocampal volumes. However, its effects on hippocampal subfields remain to be clarified. Methods: We investigated the effects of short- and long-term lithium exposure on the hippocampus and its subfields in patients affected by bipolar I disorder (BP-I). Hippocampal subfields and total hippocampal volumes were measured in 60 subjects divided into four groups: 15 patients with BP-I who were never exposed to lithium [no-exposure group (NE)], 15 patients with BP-I exposed to lithium for <24 months [short-exposure group (SE)], 15 patients with BP-I exposed to lithium for > 24 months [long-exposure group (LE)], and 15 healthy control subjects (HC). Results: The SE and NE groups showed smaller total hippocampal volumes and smaller bilateral cornu ammonis CA2-3, CA4-dentate gyrus (DG), presubiculum, and subiculum volumes compared with HC. The LE group showed larger total hippocampal volumes and bilateral CA2-3, left CA4-DG, left presubiculum, and right subiculum volumes compared with the NE group, and larger volumes of the right CA2-3, left CA4-DG, left presubiculum, and right subiculum compared with the SE group. No differences were found between the LE group and HC or between the SE and NE groups. Conclusions: Long-term, but not short-term, exposure to lithium treatment may exert neuroprotective effects on specific hippocampal subfields linked to disease progression.

AB - Objectives: Patients diagnosed with bipolar disorder (BP) may experience hippocampal atrophy. Lithium exposure has been associated with increased hippocampal volumes. However, its effects on hippocampal subfields remain to be clarified. Methods: We investigated the effects of short- and long-term lithium exposure on the hippocampus and its subfields in patients affected by bipolar I disorder (BP-I). Hippocampal subfields and total hippocampal volumes were measured in 60 subjects divided into four groups: 15 patients with BP-I who were never exposed to lithium [no-exposure group (NE)], 15 patients with BP-I exposed to lithium for <24 months [short-exposure group (SE)], 15 patients with BP-I exposed to lithium for > 24 months [long-exposure group (LE)], and 15 healthy control subjects (HC). Results: The SE and NE groups showed smaller total hippocampal volumes and smaller bilateral cornu ammonis CA2-3, CA4-dentate gyrus (DG), presubiculum, and subiculum volumes compared with HC. The LE group showed larger total hippocampal volumes and bilateral CA2-3, left CA4-DG, left presubiculum, and right subiculum volumes compared with the NE group, and larger volumes of the right CA2-3, left CA4-DG, left presubiculum, and right subiculum compared with the SE group. No differences were found between the LE group and HC or between the SE and NE groups. Conclusions: Long-term, but not short-term, exposure to lithium treatment may exert neuroprotective effects on specific hippocampal subfields linked to disease progression.

KW - bipolar disorder

KW - hippocampal subfields

KW - hippocampus

KW - lithium

KW - treatment

UR - http://www.scopus.com/inward/record.url?scp=84976645950&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84976645950&partnerID=8YFLogxK

U2 - 10.1111/bdi.12394

DO - 10.1111/bdi.12394

M3 - Article

C2 - 27237705

AN - SCOPUS:84976645950

VL - 18

SP - 352

EP - 362

JO - Bipolar Disorders

JF - Bipolar Disorders

SN - 1398-5647

IS - 4

ER -