Hippocampi, thalami, and accumbens microstructural damage in schizophrenia: A volumetry, diffusivity, and neuropsychological study

Ilaria Spoletini, Andrea Cherubini, Giulia Banfi, Ivo Alex Rubino, Patrice Peran, Carlo Caltagirone, Gianfranco Spalletta

Research output: Contribution to journalArticle

Abstract

Volumetric abnormalities in the subcortical structures have been described in schizophrenia. However, it still has to be clarified if subtle microstructural damage is also present. Thus, we aimed to detect subcortical volume and mean diffusivity (MD) alterations in 45 patients with diagnosis of schizophrenia compared with 45 age-, gender-, and educational attainment-matched healthy comparison (HC) participants, by using a combined volumetry and diffusion tensor imaging (DTI) method. A secondary aim was to identify the neuropsychological correlates of subcortical abnormalities in the schizophrenic group. We found thalami and hippocampi bilaterally and left accumbens to show MD increase in the schizophrenic group. No volumetric decrease was found. Moreover, significant correlations between the MD values in subcortical structures (right thalamus and hippocampus and left accumbens) and working memory performance were found. Thus, subcortical microstructural alterations are present in schizophrenia even in absence of volumetric abnormalities. Furthermore, microstructural damage in subcortical areas is linked to working memory, suggesting the presence of a subtle microstructural subcortical dysfunction in the pathoetiological mechanism underlying high cognitive load performances in schizophrenia. Finally, our findings indicate that MD is a more sensitive marker of brain tissue deficits than signal intensity variations measured in T1-weighted imaging data, consistently with previous reports. Thus, DTI appears to be an invaluable tool to investigate subcortical pathology in schizophrenia, greatly enhancing the ability to detect subtle brain changes in this complex disorder.

Original languageEnglish
Pages (from-to)118-130
Number of pages13
JournalSchizophrenia Bulletin
Volume37
Issue number1
DOIs
Publication statusPublished - Jan 2011

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Thalamus
Hippocampus
Schizophrenia
Diffusion Tensor Imaging
Short-Term Memory
Aptitude
Brain
Healthy Volunteers
Pathology

Keywords

  • mean diffusivity
  • subcortical structure
  • volume
  • working memory

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Hippocampi, thalami, and accumbens microstructural damage in schizophrenia : A volumetry, diffusivity, and neuropsychological study. / Spoletini, Ilaria; Cherubini, Andrea; Banfi, Giulia; Rubino, Ivo Alex; Peran, Patrice; Caltagirone, Carlo; Spalletta, Gianfranco.

In: Schizophrenia Bulletin, Vol. 37, No. 1, 01.2011, p. 118-130.

Research output: Contribution to journalArticle

Spoletini, Ilaria ; Cherubini, Andrea ; Banfi, Giulia ; Rubino, Ivo Alex ; Peran, Patrice ; Caltagirone, Carlo ; Spalletta, Gianfranco. / Hippocampi, thalami, and accumbens microstructural damage in schizophrenia : A volumetry, diffusivity, and neuropsychological study. In: Schizophrenia Bulletin. 2011 ; Vol. 37, No. 1. pp. 118-130.
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