Histamine and hypoxic pulmonary hypertension A quantitative study

Franco Rengo, Bruno Trimarco, Massimo Chiariello, Bruno Ricciardelli, Massimo Volpe, Roberto Violini, Gerardo Rasetti

Research output: Contribution to journalArticlepeer-review


Summary: Hypoxia is the most effective and consistent stimulus to pulmonary hypertension in all species; however, the genesis of this phenomenon is still unclear. Histamine has been proposed as the possible mediator of this response and extensively studied. However, there remain doubts as to its behaviour in the different vascular districts during hypoxia. Accordingly, in seven dogs, histamine content was measured in the distal vena cava, hepatic vein, pulmonary artery and aorta; pulmonary artery pressure and systemic arterial pressure were also recorded. All measurements were repeated after 5 min of breathing a mixture containing 8% oxygen. Histamine content in the pulmonary artery blood was significantly increased during hypoxia (from 29 ± 3 to 36 ± 3 ng·cm-3 P-3 (P

Original languageEnglish
Pages (from-to)752-757
Number of pages6
JournalCardiovascular Research
Issue number12
Publication statusPublished - Dec 1978

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Cardiology and Cardiovascular Medicine


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