Histamine mediation in muscular vasodilatation induced by beta adrenoceptor stimulation in dogs

F. Rengo, B. Trimarco, M. Chiariello, M. Volpe, B. Ricciardelli, G. Rasetti, L. Sacca

Research output: Contribution to journalArticle

Abstract

This study was designed to investigate the possibility of a histamine mediation in muscular vasodilatation induced by beta adrenoceptor stimulation. Accordingly, in seven dogs the effects of isoproterenol administration on the release of 14C-histamine from the perfused gracilis muscle were studied. Beta adrenoceptors stimulation induced a vasodilatation, as shown by a decrease in perfusion pressure (-43 ± 12 mm Hg); simultaneously, a significant increase of the radioactivity measured in the venous blood effluent from the gracilis muscle was observed. Both these events were blocked by propranolol. In the other five dogs, chlorpheniramine was able to reduce the vasodilatation induced by the injection in the gracilis muscle of isoproterenol. Under control conditions, isoproterenol induced a fall in perfusion pressure of 44 ± 5 mm Hg while, after chlorpheniramine, perfusion pressure decreased by only 24 ± 4 mm Hg. The results of this study seem to confirm the possibility of a histamine mediation in isoproterenol-induced vasodilatation. However, further investigation is needed in order to identify the exact role of histamine in the genesis of this phenomenon.

Original languageEnglish
Pages (from-to)30-37
Number of pages8
JournalJournal of Pharmacology and Experimental Therapeutics
Volume203
Issue number1
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Pharmacology

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    Rengo, F., Trimarco, B., Chiariello, M., Volpe, M., Ricciardelli, B., Rasetti, G., & Sacca, L. (1977). Histamine mediation in muscular vasodilatation induced by beta adrenoceptor stimulation in dogs. Journal of Pharmacology and Experimental Therapeutics, 203(1), 30-37.