RECETTORI PER L'ISTAMINA NEL SNC: RUOLO NELLA TERAPIA DEI DISTURBI DELL'EQUILIBRIO

Translated title of the contribution: Histamine receptors in the central nervous system (CNS): Role in the therapy of equillibrium disorders

F. Ottaviani

Research output: Contribution to journalArticle

Abstract

Three types of histamine receptors (H1, H2, H3) can be identified in the central nervous system (CNS) as in other apparatus. These act as mediators of the numerous histological and neuro-modulators processes for vascular and digestive phenomena. Over the past few years the role of histamine as a neurotransmitter at the level of CNS has been more clearly defined following the identification of histaminergic nervous pathway and specific receptors for this substance also present on non-histaminergic neurons. In particular; the recent identification of H3 receptors able to modulate the release of histamine and other neurotransmitter at synaptic level, throws new light on our understanding of the mechanisms of action of some drugs, such as betahistine, a molecule with a high level of H3 antagonist activity. This review aims to examine in detail the characteristics of histamine receptors in the CNS and in particular their role in the treatment of balance disorders.

Translated title of the contributionHistamine receptors in the central nervous system (CNS): Role in the therapy of equillibrium disorders
Original languageItalian
Pages (from-to)85-89
Number of pages5
JournalOtorinolaringologia
Volume45
Issue number3
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Otorhinolaryngology

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