Abstract
A 44-yr-old man presented with fever, progressive weight loss, anemia, lumbar back pain and subsequent paraparesis with sensory level at D 12-L 1. Radiographic and myelographic studies revealed lysis of D 11-L 2 and 2 extradural lesions at D 4 and D 11 respectively. Diagnosis of histiocytic medullary reticulosis (HMR) was made by histological examination of lymph nodes. Cerebrospinal fluid and bone marrow were invaded by malignant histiocytes. The administration of chemotherapy with adriamycin, vincristine and prednisone (HOP), intrathecal methotrexate and direct field cobalt radiotherapy did not result in any major clinical improvement. Central nervous system involvement in HMR is associated with a poor prognosis and warrants investigations analogous to those in advanced non-Hodgkin lymphomas with unfavorable histology.
| Original language | English |
|---|---|
| Pages (from-to) | 187-190 |
| Number of pages | 4 |
| Journal | Clinical Oncology |
| Volume | 6 |
| Issue number | 2 |
| Publication status | Published - 1980 |
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ASJC Scopus subject areas
- Surgery
- Oncology
Cite this
Histiocytic medullary reticulosis with spinal cord compression at presentation. / Veronesi, A.; Carbone, A.; Tirelli, U.; Galligioni, E.; Volpe, R.; Crivellari, D.; Trovó, M. G.; Canale, V. C.; Tumolo, S.; Grigoletto, E.
In: Clinical Oncology, Vol. 6, No. 2, 1980, p. 187-190.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Histiocytic medullary reticulosis with spinal cord compression at presentation
AU - Veronesi, A.
AU - Carbone, A.
AU - Tirelli, U.
AU - Galligioni, E.
AU - Volpe, R.
AU - Crivellari, D.
AU - Trovó, M. G.
AU - Canale, V. C.
AU - Tumolo, S.
AU - Grigoletto, E.
PY - 1980
Y1 - 1980
N2 - A 44-yr-old man presented with fever, progressive weight loss, anemia, lumbar back pain and subsequent paraparesis with sensory level at D 12-L 1. Radiographic and myelographic studies revealed lysis of D 11-L 2 and 2 extradural lesions at D 4 and D 11 respectively. Diagnosis of histiocytic medullary reticulosis (HMR) was made by histological examination of lymph nodes. Cerebrospinal fluid and bone marrow were invaded by malignant histiocytes. The administration of chemotherapy with adriamycin, vincristine and prednisone (HOP), intrathecal methotrexate and direct field cobalt radiotherapy did not result in any major clinical improvement. Central nervous system involvement in HMR is associated with a poor prognosis and warrants investigations analogous to those in advanced non-Hodgkin lymphomas with unfavorable histology.
AB - A 44-yr-old man presented with fever, progressive weight loss, anemia, lumbar back pain and subsequent paraparesis with sensory level at D 12-L 1. Radiographic and myelographic studies revealed lysis of D 11-L 2 and 2 extradural lesions at D 4 and D 11 respectively. Diagnosis of histiocytic medullary reticulosis (HMR) was made by histological examination of lymph nodes. Cerebrospinal fluid and bone marrow were invaded by malignant histiocytes. The administration of chemotherapy with adriamycin, vincristine and prednisone (HOP), intrathecal methotrexate and direct field cobalt radiotherapy did not result in any major clinical improvement. Central nervous system involvement in HMR is associated with a poor prognosis and warrants investigations analogous to those in advanced non-Hodgkin lymphomas with unfavorable histology.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018835205&partnerID=8YFLogxK
M3 - Article
VL - 6
SP - 187
EP - 190
JO - Clinical Oncology
JF - Clinical Oncology
SN - 0305-7399
IS - 2
ER -