Histiocytic medullary reticulosis with spinal cord compression at presentation

A. Veronesi; A. Carbone; U. Tirelli; E. Galligioni; R. Volpe; D. Crivellari; M. G. Trovó; V. C. Canale; S. Tumolo; E. Grigoletto

Histiocytic medullary reticulosis with spinal cord compression at presentation

A. Veronesi, A. Carbone, U. Tirelli, E. Galligioni, R. Volpe, D. Crivellari, M. G. Trovó, V. C. Canale, S. Tumolo, E. Grigoletto

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

A 44-yr-old man presented with fever, progressive weight loss, anemia, lumbar back pain and subsequent paraparesis with sensory level at D ₁₂-L ₁. Radiographic and myelographic studies revealed lysis of D ₁₁-L ₂ and 2 extradural lesions at D ₄ and D ₁₁ respectively. Diagnosis of histiocytic medullary reticulosis (HMR) was made by histological examination of lymph nodes. Cerebrospinal fluid and bone marrow were invaded by malignant histiocytes. The administration of chemotherapy with adriamycin, vincristine and prednisone (HOP), intrathecal methotrexate and direct field cobalt radiotherapy did not result in any major clinical improvement. Central nervous system involvement in HMR is associated with a poor prognosis and warrants investigations analogous to those in advanced non-Hodgkin lymphomas with unfavorable histology.

Original language	English
Pages (from-to)	187-190
Number of pages	4
Journal	Clinical Oncology
Volume	6
Issue number	2
Publication status	Published - 1980

ASJC Scopus subject areas

Surgery
Oncology

Cite this

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title = "Histiocytic medullary reticulosis with spinal cord compression at presentation",

abstract = "A 44-yr-old man presented with fever, progressive weight loss, anemia, lumbar back pain and subsequent paraparesis with sensory level at D 12-L 1. Radiographic and myelographic studies revealed lysis of D 11-L 2 and 2 extradural lesions at D 4 and D 11 respectively. Diagnosis of histiocytic medullary reticulosis (HMR) was made by histological examination of lymph nodes. Cerebrospinal fluid and bone marrow were invaded by malignant histiocytes. The administration of chemotherapy with adriamycin, vincristine and prednisone (HOP), intrathecal methotrexate and direct field cobalt radiotherapy did not result in any major clinical improvement. Central nervous system involvement in HMR is associated with a poor prognosis and warrants investigations analogous to those in advanced non-Hodgkin lymphomas with unfavorable histology.",

author = "A. Veronesi and A. Carbone and U. Tirelli and E. Galligioni and R. Volpe and D. Crivellari and Trov{\'o}, {M. G.} and Canale, {V. C.} and S. Tumolo and E. Grigoletto",

year = "1980",

language = "English",

volume = "6",

pages = "187--190",

journal = "Clinical Oncology",

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T1 - Histiocytic medullary reticulosis with spinal cord compression at presentation

AU - Veronesi, A.

AU - Carbone, A.

AU - Tirelli, U.

AU - Galligioni, E.

AU - Volpe, R.

AU - Crivellari, D.

AU - Trovó, M. G.

AU - Canale, V. C.

AU - Tumolo, S.

AU - Grigoletto, E.

PY - 1980

Y1 - 1980

N2 - A 44-yr-old man presented with fever, progressive weight loss, anemia, lumbar back pain and subsequent paraparesis with sensory level at D 12-L 1. Radiographic and myelographic studies revealed lysis of D 11-L 2 and 2 extradural lesions at D 4 and D 11 respectively. Diagnosis of histiocytic medullary reticulosis (HMR) was made by histological examination of lymph nodes. Cerebrospinal fluid and bone marrow were invaded by malignant histiocytes. The administration of chemotherapy with adriamycin, vincristine and prednisone (HOP), intrathecal methotrexate and direct field cobalt radiotherapy did not result in any major clinical improvement. Central nervous system involvement in HMR is associated with a poor prognosis and warrants investigations analogous to those in advanced non-Hodgkin lymphomas with unfavorable histology.

AB - A 44-yr-old man presented with fever, progressive weight loss, anemia, lumbar back pain and subsequent paraparesis with sensory level at D 12-L 1. Radiographic and myelographic studies revealed lysis of D 11-L 2 and 2 extradural lesions at D 4 and D 11 respectively. Diagnosis of histiocytic medullary reticulosis (HMR) was made by histological examination of lymph nodes. Cerebrospinal fluid and bone marrow were invaded by malignant histiocytes. The administration of chemotherapy with adriamycin, vincristine and prednisone (HOP), intrathecal methotrexate and direct field cobalt radiotherapy did not result in any major clinical improvement. Central nervous system involvement in HMR is associated with a poor prognosis and warrants investigations analogous to those in advanced non-Hodgkin lymphomas with unfavorable histology.

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Histiocytic medullary reticulosis with spinal cord compression at presentation

Abstract

ASJC Scopus subject areas

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