A 44-yr-old man presented with fever, progressive weight loss, anemia, lumbar back pain and subsequent paraparesis with sensory level at D 12-L 1. Radiographic and myelographic studies revealed lysis of D 11-L 2 and 2 extradural lesions at D 4 and D 11 respectively. Diagnosis of histiocytic medullary reticulosis (HMR) was made by histological examination of lymph nodes. Cerebrospinal fluid and bone marrow were invaded by malignant histiocytes. The administration of chemotherapy with adriamycin, vincristine and prednisone (HOP), intrathecal methotrexate and direct field cobalt radiotherapy did not result in any major clinical improvement. Central nervous system involvement in HMR is associated with a poor prognosis and warrants investigations analogous to those in advanced non-Hodgkin lymphomas with unfavorable histology.
|Number of pages||4|
|Publication status||Published - 1980|
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