Histiocytic necrotizing lymphadenitis (Kikuchi's disease)

G. Soda, D. Bosco, A. Baiocchini, M. Melis

Research output: Contribution to journalArticlepeer-review


We present a case report of a young asiatic woman presenting Kikuchi's lymphadenitis, a suprahyoidea mass, pharyngitis, fever, weakness and lack of appetite. The clinical picture quickly improved after biopsy until complete remission within two months. Sierologic studies showed significant antibody titres revealing a previous EBV infection; they were also negative for Toxotest, HbsAg, HIV and serogroup 3 and 9 Yersinia Enterocolitica. Histological findings showed necrotic changes and large foci of infiltration in the cortex and/or paracortex. They consisted of variable numbers of small lymphocytes, immunoblasts, macrophages and so-called plasmacytoid monocytes, neutrophils were absent. Immunohistochemistry revealed within the lesion T-Lymphocytes displaying a phenotype CD4+ while T-Lymphocytes CD8+ were observed in the paracortex and in the peripheral region of the lesion.

Original languageEnglish
Pages (from-to)192-195
Number of pages4
Issue number3
Publication statusPublished - 1996


  • Kikuchi's disease
  • Kikuchi's lymphadenitis
  • Suprahyoidea lymphadenitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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