Abstract
Twenty-seven cases of an unusual necrotizing lymphadenitis previously described only in Japan are reported as occurring in West Germany (23 cases), Iran (1 case), Italy (1 case), Korea (1 case) and Spain (1 case). The lesion frequently develops in the cervical lymph nodes of young women. It is characterized by infiltration of the cortex and/or paracortex by large collections of proliferating histiocytes and is devoid of granulocytes. Complete or, more often, incomplete necrosis of lymphoid tissue is seen in all cases. In cases with incomplete necrosis, the histiocytes are interspersed with pyknotic cells and nuclear debris. Based on the histological findings, the term "histiocytic necrotizing lymphadenitis without granulocytic infiltration" is proposed. Lesions to be considered in a differential diagnosis are malignant histiocytic neoplasms and necrotizing lymphadenitis with granulocytic infiltration, which is seen in lupus erythematosus and bacterial infections. The aetiology of histiocytic necrotizing lymphadenitis without granulocytic infiltration is still unclear. Some clinical and histological features indicate the possibility of an underlying viral infection.
| Original language | English |
|---|---|
| Pages (from-to) | 257-271 |
| Number of pages | 15 |
| Journal | Virchows Archiv A Pathological Anatomy and Histology |
| Volume | 395 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 1982 |
Fingerprint
Keywords
- Histiocytic lymphadenitis
- Lupus erythematosus
- Necrotizing lymphadenitis
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Anatomy
Cite this
Histiocytic necrotizing lymphadenitis without granulocytic infiltration. / Pileri, S.; Kikuchi, M.; Helbron, Dagmar; Lennert, K.
In: Virchows Archiv A Pathological Anatomy and Histology, Vol. 395, No. 3, 05.1982, p. 257-271.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Histiocytic necrotizing lymphadenitis without granulocytic infiltration
AU - Pileri, S.
AU - Kikuchi, M.
AU - Helbron, Dagmar
AU - Lennert, K.
PY - 1982/5
Y1 - 1982/5
N2 - Twenty-seven cases of an unusual necrotizing lymphadenitis previously described only in Japan are reported as occurring in West Germany (23 cases), Iran (1 case), Italy (1 case), Korea (1 case) and Spain (1 case). The lesion frequently develops in the cervical lymph nodes of young women. It is characterized by infiltration of the cortex and/or paracortex by large collections of proliferating histiocytes and is devoid of granulocytes. Complete or, more often, incomplete necrosis of lymphoid tissue is seen in all cases. In cases with incomplete necrosis, the histiocytes are interspersed with pyknotic cells and nuclear debris. Based on the histological findings, the term "histiocytic necrotizing lymphadenitis without granulocytic infiltration" is proposed. Lesions to be considered in a differential diagnosis are malignant histiocytic neoplasms and necrotizing lymphadenitis with granulocytic infiltration, which is seen in lupus erythematosus and bacterial infections. The aetiology of histiocytic necrotizing lymphadenitis without granulocytic infiltration is still unclear. Some clinical and histological features indicate the possibility of an underlying viral infection.
AB - Twenty-seven cases of an unusual necrotizing lymphadenitis previously described only in Japan are reported as occurring in West Germany (23 cases), Iran (1 case), Italy (1 case), Korea (1 case) and Spain (1 case). The lesion frequently develops in the cervical lymph nodes of young women. It is characterized by infiltration of the cortex and/or paracortex by large collections of proliferating histiocytes and is devoid of granulocytes. Complete or, more often, incomplete necrosis of lymphoid tissue is seen in all cases. In cases with incomplete necrosis, the histiocytes are interspersed with pyknotic cells and nuclear debris. Based on the histological findings, the term "histiocytic necrotizing lymphadenitis without granulocytic infiltration" is proposed. Lesions to be considered in a differential diagnosis are malignant histiocytic neoplasms and necrotizing lymphadenitis with granulocytic infiltration, which is seen in lupus erythematosus and bacterial infections. The aetiology of histiocytic necrotizing lymphadenitis without granulocytic infiltration is still unclear. Some clinical and histological features indicate the possibility of an underlying viral infection.
KW - Histiocytic lymphadenitis
KW - Lupus erythematosus
KW - Necrotizing lymphadenitis
UR - http://www.scopus.com/inward/record.url?scp=0019983004&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019983004&partnerID=8YFLogxK
U2 - 10.1007/BF00429352
DO - 10.1007/BF00429352
M3 - Article
C2 - 7112935
AN - SCOPUS:0019983004
VL - 395
SP - 257
EP - 271
JO - Virchows Archiv - A Pathological Anatomy and Histopathology
JF - Virchows Archiv - A Pathological Anatomy and Histopathology
SN - 0945-6317
IS - 3
ER -