Histiocytic sarcoma with interdigitating dendritic cell differentiation

David W. Porter, Girish L. Gupte, Rachel M. Brown, Chris Spray, Martin W. English, Jean DeVille DeGoyet, Patrick J. McKiernan

Research output: Contribution to journalArticlepeer-review

Abstract

The authors describe a rare tumor with overlapping features of true histiocytic sarcoma and interdigitating dendritic cell sarcoma occurring in infancy. A 3-month-old boy presented with hepatosplenomegaly and abdominal distention. He presented a diagnostic challenge at initial presentation despite extensive investigations. On follow-up at age 16 months he had progressive splenomegaly, thrombocytopenia, and worsening coagulopathy. A diagnosis of histiocytic sarcoma with interdigitating dendritic cell differentiation was established after an open biopsy of liver and spleen. A repeat liver biopsy coupled with splenic biopsy is recommended in young children with unexplained hepatosplenomegaly and thrombocytopenia.

Original languageEnglish
Pages (from-to)827-830
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume26
Issue number12
Publication statusPublished - Dec 2004

Keywords

  • Histiocytic sarcoma
  • Histiocytic tumors
  • Interdigitating dendritic cell sarcoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

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