Histochemical and ultrastructural study of an elastofibroma dorsi coexisting with a high grade spindle cell sarcoma

M. Alberghini, P. Bacchini, G. Pignatti, M. C. Maltarello, L. Zanella, N. M. Maraldi, F. Bertoni

Research output: Contribution to journalArticlepeer-review

Abstract

Elastofibroma dorsi is a pseudotumoral fibroproliferative lesion characterized by polymorphic fiber-like deposits of elastinophilic material. Several theories have been reported explaining the pathogenesis of elastofibroma. Recent cytogenetic studies have demonstrated chromosomal instability in elastofibromas, not normally observed in non-neoplastic tissues. These chromosomal defects are commonly observed in aggressive fibromatosis too. Such clinical observations suggest a multistage pathogenetic mechanism for the onset of elastofibroma. This study, using histochemical, immunohistochemical staining techniques, and ultrastructural examination, describes the detection of an otherwise typical elastofibroma contextual to a high grade sarcoma. Hence, the coexistence of elastofibroma and high-grade sarcoma may suggest a causal link between the two pathological entities. The results obtained suggest that the coexistence of the two pathological entities is conceivably coincidental.

Original languageEnglish
Pages (from-to)173-177
Number of pages5
JournalEuropean journal of histochemistry : EJH
Volume48
Issue number2
Publication statusPublished - 2004

Keywords

  • Elastofibroma
  • Leiomyosarcoma
  • Pseudotumoral lesions

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Animal Science and Zoology
  • Developmental Biology

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