STUDIO ISTOLOGICO DELLA MUSCOLATURA EXTRAOCULARE NELLE COSIDETTE 'OFTALMOPLEGIE NUCLEARI PROGRESSIVE'

Translated title of the contribution: Histologic alterations in extraocular muscles in the so called 'progressive nuclear ophthalmoplegia'

G. Scarlato, G. Pellegrini, G. Meola

Research output: Contribution to journalArticlepeer-review

Abstract

The histologic and histochemical changes are described as found in muscle biopsies of 21 patients with progressive external ophthalmoplegia - either pure or associated with other disorders. In agreement with the literature, the most important and frequent histologic alterations were the presence of scattered ragged red fibers. From a histochemical point of view, conspicuous changes of the mitochondrial enzymes were found in these fibers. Though such changes are not specific, the authors believe that mitochondrial alterations are one of the possible morphologic and functional basic disturbances for progressive external ophthalmoplegia. Involvement of mitochondria must always be suspected in this syndrome.

Translated title of the contributionHistologic alterations in extraocular muscles in the so called 'progressive nuclear ophthalmoplegia'
Original languageItalian
Pages (from-to)93-99
Number of pages7
JournalActa Neurologica
Volume31
Issue number1
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Clinical Neurology

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