Abstract
The histologic and histochemical changes are described as found in muscle biopsies of 21 patients with progressive external ophthalmoplegia - either pure or associated with other disorders. In agreement with the literature, the most important and frequent histologic alterations were the presence of scattered ragged red fibers. From a histochemical point of view, conspicuous changes of the mitochondrial enzymes were found in these fibers. Though such changes are not specific, the authors believe that mitochondrial alterations are one of the possible morphologic and functional basic disturbances for progressive external ophthalmoplegia. Involvement of mitochondria must always be suspected in this syndrome.
| Original language | Italian |
|---|---|
| Pages (from-to) | 93-99 |
| Number of pages | 7 |
| Journal | Acta Neurologica |
| Volume | 31 |
| Issue number | 1 |
| Publication status | Published - 1976 |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
STUDIO ISTOLOGICO DELLA MUSCOLATURA EXTRAOCULARE NELLE COSIDETTE 'OFTALMOPLEGIE NUCLEARI PROGRESSIVE'. / Scarlato, G.; Pellegrini, G.; Meola, G.
In: Acta Neurologica, Vol. 31, No. 1, 1976, p. 93-99.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - STUDIO ISTOLOGICO DELLA MUSCOLATURA EXTRAOCULARE NELLE COSIDETTE 'OFTALMOPLEGIE NUCLEARI PROGRESSIVE'
AU - Scarlato, G.
AU - Pellegrini, G.
AU - Meola, G.
PY - 1976
Y1 - 1976
N2 - The histologic and histochemical changes are described as found in muscle biopsies of 21 patients with progressive external ophthalmoplegia - either pure or associated with other disorders. In agreement with the literature, the most important and frequent histologic alterations were the presence of scattered ragged red fibers. From a histochemical point of view, conspicuous changes of the mitochondrial enzymes were found in these fibers. Though such changes are not specific, the authors believe that mitochondrial alterations are one of the possible morphologic and functional basic disturbances for progressive external ophthalmoplegia. Involvement of mitochondria must always be suspected in this syndrome.
AB - The histologic and histochemical changes are described as found in muscle biopsies of 21 patients with progressive external ophthalmoplegia - either pure or associated with other disorders. In agreement with the literature, the most important and frequent histologic alterations were the presence of scattered ragged red fibers. From a histochemical point of view, conspicuous changes of the mitochondrial enzymes were found in these fibers. Though such changes are not specific, the authors believe that mitochondrial alterations are one of the possible morphologic and functional basic disturbances for progressive external ophthalmoplegia. Involvement of mitochondria must always be suspected in this syndrome.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017284050&partnerID=8YFLogxK
M3 - Articolo
C2 - 61714
AN - SCOPUS:0017284050
VL - 31
SP - 93
EP - 99
JO - Acta Neurologica
JF - Acta Neurologica
SN - 0001-6276
IS - 1
ER -