Histologic changes in type A chronic atrophic gastritis indicating increased risk of neuroendocrine tumor development: The predictive role of dysplastic and severely hyperplastic enterochromaffin-like cell lesions

Alessandro Vanoli, Stefano La Rosa, Ombretta Luinetti, Catherine Klersy, Rachele Manca, Costanza Alvisi, Sandro Rossi, Erminio Trespi, Adriano Zangrandi, Fausto Sessa, Carlo Capella, Enrico Solcia

Research output: Contribution to journalArticlepeer-review

Abstract

The role of putative preneoplastic enterochromaffin-like cell lesions, either hyperplastic or dysplastic, in the genesis of type 1 enterochromaffin- like cell neuroendocrine tumors associated with type A chronic atrophic gastritis, their actual neoplastic risk, and their precise histogenetic mechanism deserve further clarification by specific histopathologic studies coupled with patient follow-up. A total of 100 patients with severe type A chronic atrophic gastritis, enterochromaffin-like cell hyperplasia, and antral G-cell hyperplasia were endoscopically and histologically followed up for a median of 90.1 months (total of 9118 person-months). Preneoplastic enterochromaffin-like cell lesions and newly developed neuroendocrine tumors were investigated histologically and histochemically, in parallel with enterochromaffin-like cell lesions found in nontumor mucosa of another 32 well-characterized and previously reported type 1 neuroendocrine tumors. Both neuroendocrine and nonneuroendocrine mucosa changes were analyzed and statistically evaluated. During follow-up, 7 of 100 patients developed neuroendocrine tumors: 5 were in a group of 20 cases with previous enterochromaffin-like cell dysplasia and 2 were among 80 cases showing only enterochromaffin-like cell hyperplasia throughout the study (hazard ratio, 20.7; P

Original languageEnglish
Pages (from-to)1827-1837
Number of pages11
JournalHuman Pathology
Volume44
Issue number9
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Dysplasia
  • ECL cell
  • Hyperplasia
  • Neuroendocrine tumor
  • Preneoplastic lesions
  • Stomach

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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