Healing of partial and osteochondral surgical cartilaginous lesions to the rabbit femur was studied histologically to determine healing time and quality of the repaired/regenerated tissue, so as to construct an experimental in vivo model for the evaluation of medical and/or surgical therapies, which so far have not ensured complete resolution of the cartilaginous defects. In eighteen New Zealand rabbits, an osteochondral lesion (2.5 × 2 mm) was drilled in the right femoral medial condyle by lateral cutaneous incision and arthrotomy of each knee was performed, while, a chondral lesion (1.25±0.2 × 0.8±0.2 mm) was created in the left femoral medial condyle of each rabbit. Results showed no healing of the chondral defect and an abnormal bony growth beyond the articular profile with a fibrous coating, even at 12 weeks in osteochondral lesion.
|Number of pages||8|
|Journal||Journal of Applied Animal Research|
|Publication status||Published - 2000|
- Animal model
ASJC Scopus subject areas
- Animal Science and Zoology