Histologic Evaluation of the Repair Process of Chondral and Osteochondral Lesions in a Rabbit Model

G. A. Guzzardella, G. Morrone, M. Fini, M. Rocca, P. Torricelli, R. Giardino

Research output: Contribution to journalArticlepeer-review

Abstract

Healing of partial and osteochondral surgical cartilaginous lesions to the rabbit femur was studied histologically to determine healing time and quality of the repaired/regenerated tissue, so as to construct an experimental in vivo model for the evaluation of medical and/or surgical therapies, which so far have not ensured complete resolution of the cartilaginous defects. In eighteen New Zealand rabbits, an osteochondral lesion (2.5 × 2 mm) was drilled in the right femoral medial condyle by lateral cutaneous incision and arthrotomy of each knee was performed, while, a chondral lesion (1.25±0.2 × 0.8±0.2 mm) was created in the left femoral medial condyle of each rabbit. Results showed no healing of the chondral defect and an abnormal bony growth beyond the articular profile with a fibrous coating, even at 12 weeks in osteochondral lesion.

Original languageEnglish
Pages (from-to)217-224
Number of pages8
JournalJournal of Applied Animal Research
Volume17
Issue number2
Publication statusPublished - 2000

Keywords

  • Animal model
  • Cartilage
  • Healing
  • Rabbit

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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