Histologic Evaluation of the Repair Process of Chondral and Osteochondral Lesions in a Rabbit Model

G. A. Guzzardella, G. Morrone, M. Fini, M. Rocca, P. Torricelli, R. Giardino

Research output: Contribution to journalArticle

Abstract

Healing of partial and osteochondral surgical cartilaginous lesions to the rabbit femur was studied histologically to determine healing time and quality of the repaired/regenerated tissue, so as to construct an experimental in vivo model for the evaluation of medical and/or surgical therapies, which so far have not ensured complete resolution of the cartilaginous defects. In eighteen New Zealand rabbits, an osteochondral lesion (2.5 × 2 mm) was drilled in the right femoral medial condyle by lateral cutaneous incision and arthrotomy of each knee was performed, while, a chondral lesion (1.25±0.2 × 0.8±0.2 mm) was created in the left femoral medial condyle of each rabbit. Results showed no healing of the chondral defect and an abnormal bony growth beyond the articular profile with a fibrous coating, even at 12 weeks in osteochondral lesion.

Original languageEnglish
Pages (from-to)217-224
Number of pages8
JournalJournal of Applied Animal Research
Volume17
Issue number2
Publication statusPublished - 2000

Fingerprint

cartilage
lesions (animal)
Cartilage
rabbits
Thigh
Rabbits
thighs
Bone and Bones
Femur
knees
Knee
Joints
femur
coatings
Skin
Growth
therapeutics
Therapeutics

Keywords

  • Animal model
  • Cartilage
  • Healing
  • Rabbit

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Histologic Evaluation of the Repair Process of Chondral and Osteochondral Lesions in a Rabbit Model. / Guzzardella, G. A.; Morrone, G.; Fini, M.; Rocca, M.; Torricelli, P.; Giardino, R.

In: Journal of Applied Animal Research, Vol. 17, No. 2, 2000, p. 217-224.

Research output: Contribution to journalArticle

@article{cd432dfa1b8b43aa95c8e4464c15c5b7,
title = "Histologic Evaluation of the Repair Process of Chondral and Osteochondral Lesions in a Rabbit Model",
abstract = "Healing of partial and osteochondral surgical cartilaginous lesions to the rabbit femur was studied histologically to determine healing time and quality of the repaired/regenerated tissue, so as to construct an experimental in vivo model for the evaluation of medical and/or surgical therapies, which so far have not ensured complete resolution of the cartilaginous defects. In eighteen New Zealand rabbits, an osteochondral lesion (2.5 × 2 mm) was drilled in the right femoral medial condyle by lateral cutaneous incision and arthrotomy of each knee was performed, while, a chondral lesion (1.25±0.2 × 0.8±0.2 mm) was created in the left femoral medial condyle of each rabbit. Results showed no healing of the chondral defect and an abnormal bony growth beyond the articular profile with a fibrous coating, even at 12 weeks in osteochondral lesion.",
keywords = "Animal model, Cartilage, Healing, Rabbit",
author = "Guzzardella, {G. A.} and G. Morrone and M. Fini and M. Rocca and P. Torricelli and R. Giardino",
year = "2000",
language = "English",
volume = "17",
pages = "217--224",
journal = "Journal of Applied Animal Research",
issn = "0971-2119",
publisher = "Garuda Scientific Publications",
number = "2",

}

TY - JOUR

T1 - Histologic Evaluation of the Repair Process of Chondral and Osteochondral Lesions in a Rabbit Model

AU - Guzzardella, G. A.

AU - Morrone, G.

AU - Fini, M.

AU - Rocca, M.

AU - Torricelli, P.

AU - Giardino, R.

PY - 2000

Y1 - 2000

N2 - Healing of partial and osteochondral surgical cartilaginous lesions to the rabbit femur was studied histologically to determine healing time and quality of the repaired/regenerated tissue, so as to construct an experimental in vivo model for the evaluation of medical and/or surgical therapies, which so far have not ensured complete resolution of the cartilaginous defects. In eighteen New Zealand rabbits, an osteochondral lesion (2.5 × 2 mm) was drilled in the right femoral medial condyle by lateral cutaneous incision and arthrotomy of each knee was performed, while, a chondral lesion (1.25±0.2 × 0.8±0.2 mm) was created in the left femoral medial condyle of each rabbit. Results showed no healing of the chondral defect and an abnormal bony growth beyond the articular profile with a fibrous coating, even at 12 weeks in osteochondral lesion.

AB - Healing of partial and osteochondral surgical cartilaginous lesions to the rabbit femur was studied histologically to determine healing time and quality of the repaired/regenerated tissue, so as to construct an experimental in vivo model for the evaluation of medical and/or surgical therapies, which so far have not ensured complete resolution of the cartilaginous defects. In eighteen New Zealand rabbits, an osteochondral lesion (2.5 × 2 mm) was drilled in the right femoral medial condyle by lateral cutaneous incision and arthrotomy of each knee was performed, while, a chondral lesion (1.25±0.2 × 0.8±0.2 mm) was created in the left femoral medial condyle of each rabbit. Results showed no healing of the chondral defect and an abnormal bony growth beyond the articular profile with a fibrous coating, even at 12 weeks in osteochondral lesion.

KW - Animal model

KW - Cartilage

KW - Healing

KW - Rabbit

UR - http://www.scopus.com/inward/record.url?scp=0000655762&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0000655762&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0000655762

VL - 17

SP - 217

EP - 224

JO - Journal of Applied Animal Research

JF - Journal of Applied Animal Research

SN - 0971-2119

IS - 2

ER -