Histologic subclassification of nodular sclerosis Hodgkin's disease

A. Carbone

Research output: Contribution to journalArticle


Nodular sclerosis (NS) Hodgkin's disease was pathologically subdivided by cellular composition and degree of fibrosis in a series of 49 children admitted to the Istituto Nazionale Tumori, Milan, between 1967 and 1977. NS showed lymphocytic predominance (LP) in 26 cases, mixed cellularity (MC) in 16 cases, and lymphocytic depletion (LD) in 7 cases. 'Early fibrosis' (EF) and 'advanced fibrosis' (AF) subgroups in 28 and 21 cases, respectively, were observed. Of the cases with LP 76.9% (20/26) presented with stages I and II disease, compared with 37.5% (6/16) and 28.6% (2/7) of the MC and LD subgroups, respectively. LP and EF subgroups coexisted in 12 of 28 (42.9%) patients at stages I and II. Predominance of lymphocytes, rarity of lacunar cells, and a mild degree of fibrosis were associated with early stages of disease. This data confirms that subclassification of NS is feasible.

Original languageEnglish
Pages (from-to)743-751
Number of pages9
Issue number6
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Cancer Research

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