Histological and functional characteristics of peritoneal membrane in peritoneal sclerosis of PD patients

S. Volmer Bertoli, L. Buzzi, D. Ciurlino, M. Maccario, L. Traversi, S. Martino, M. Procaccio

Research output: Contribution to journalArticle

Abstract

Background: Function and structure of peritoneal membrane (PM) are impaired on peritoneal dialysis (PD). Peritoneal sclerosis is a common finding in peritoneal biopsies (PB) of PD patients. The aim of this study was to examine the impact of peritoneal sclerosis on peritoneal function and clinical parameters in PD patients submitted to peritoneal biopsy. Methods: A PB was performed on 31 PD patients during catheter removal due to malfunction or after drop-out from treatment. For each patient PM transport was evaluated by the last peritoneal equilibration test before PB. Each daily glucose load was calculated. Tissue was formalin-embedded and stained for histological and immunohistochemical studies. Results: Patients with submesothelial sclerosis and those with impairment of submesothelial basement membrane and subendothelial vascular membrane were submitted to a larger daily glucose load. Peritoneal sclerosis > 50 microns was more frequent in high transporters, who were exposed to larger daily glucose load compared to medium-high transporters. Mesothelial loss is correlated to peritoneal sclerosis and vascular injuries. Conclusions: Peritoneal sclerosis is not constant in PD patients: it is related to the loss of mesothelium integrity, to the daily glucose load of PD treatment and to vascular injuries, but apparently not to the presence of inflammatory infiltrate. It remains a matter of debate how much the peritoneal sclerosis modifies the function of PM and how new more biocompatible PD solutions could reduce PM injury.

Original languageEnglish
Pages (from-to)112-116
Number of pages5
JournalInternational Journal of Artificial Organs
Volume28
Issue number2
Publication statusPublished - Feb 2005

Keywords

  • Peritoneal dialysis
  • Peritoneal function
  • Peritoneal membrane
  • Peritoneal sclerosis

ASJC Scopus subject areas

  • Biophysics

Fingerprint Dive into the research topics of 'Histological and functional characteristics of peritoneal membrane in peritoneal sclerosis of PD patients'. Together they form a unique fingerprint.

  • Cite this