Histological and immunological features of primary Kaposi's sarcoma

Evaluation before and after chemotherapy

L. Brambilla, V. Boneschi, P. D. Pigatto, A. F. Finzi, C. Marinig, P. Renoldi, G. F. Fiorini

Research output: Contribution to journalArticle

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Abstract

Forty-one patients with primary Kaposis' sarcoma (KS) have been evaluated clinically, histologically and immunologically at the time of diagnosis. There was no correlation between histological and immunological features. Moreover, the disease did not appear to be related to particular HLA phenotypes. The T4/T8 ratio was augmented. Leu 7+ cells were also significantly increased. The last 15 patients who received chemotherapy were recently reevaluated after treatment and an increase in B lymphocytes was observed. We also observed that spindle-shaped cells (SSC), which appear later in the histopathological course of the disease, disappear first during chemotherapy, concomitantly with the increase in B cells. We conclude that the course of the disease appears to be controlled by the host's immune response, though there is no clear correlation between histological and immunological evolution. Several immunological features differentiating it from AIDS associated KS have been found.

Original languageEnglish
Pages (from-to)211-217
Number of pages7
JournalActa Dermato-Venereologica
Volume67
Issue number3
Publication statusPublished - 1987

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Kaposi's Sarcoma
Disease
Drug Therapy
B-Lymphocytes
evaluation
CD4-CD8 Ratio
Acquired Immunodeficiency Syndrome
AIDS
Phenotype
Evaluation
Cells
Chemotherapy
Therapeutics

ASJC Scopus subject areas

  • Dermatology

Cite this

Histological and immunological features of primary Kaposi's sarcoma : Evaluation before and after chemotherapy. / Brambilla, L.; Boneschi, V.; Pigatto, P. D.; Finzi, A. F.; Marinig, C.; Renoldi, P.; Fiorini, G. F.

In: Acta Dermato-Venereologica, Vol. 67, No. 3, 1987, p. 211-217.

Research output: Contribution to journalArticle

Brambilla, L. ; Boneschi, V. ; Pigatto, P. D. ; Finzi, A. F. ; Marinig, C. ; Renoldi, P. ; Fiorini, G. F. / Histological and immunological features of primary Kaposi's sarcoma : Evaluation before and after chemotherapy. In: Acta Dermato-Venereologica. 1987 ; Vol. 67, No. 3. pp. 211-217.
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