This study was designed to establish the tissutal, cellular and intracellular effects induced by transrectal prostatic hyperthermia for benign prostatic hyperplasia. Fifty-five patients with a prostatic nodule suspicious for carcinoma were submitted to a transperineal ultrasound-guided prostatic biopsy. After the histological diagnosis of benign prostatic hyperplasia these patients were submitted to ten, sixty-minute long sessions of transrectal prostatic hyperthermia with a calculated intraprostatic temperature of 42 ± 0.5%C. The same patients were submitted to a control prostatic biopsy at one-month follow-up and specimens were studied under the light and electron microscope. Morphometric analysis demonstrated a significant increase in capillary-like vessels which presented with a tortuous shape, segmented swelling and thin walls. No signs of cellular damage were noted. Cell membranes and junctions were well preserved. Transrectal prostatic hyperthermia does not cause irreversible cell damage: the capillary growth observed could increase the distribution of drugs to the gland.
|Translated title of the contribution||Histological and ultrastructural changes after transrectal hyperthermia for benign prostate hyperplasia|
|Number of pages||2|
|Journal||Acta Urologica Italica|
|Issue number||SUPPL. 6|
|Publication status||Published - 1992|
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