MODIFICAZIONI ISTOLOGICHE ED ULTRASTRUTTURALI POST IPERTERMIA TRANSRETTALE NELLA IPERPLASIA PROSTATICA BENIGNA

Translated title of the contribution: Histological and ultrastructural changes after transrectal hyperthermia for benign prostate hyperplasia

F. Montorsi, R. Colombo, G. Guazzoni, L. Galli, V. Di Girolamo, E. Trabucchi, G. Bulfamante, P. Bellinzoni, P. Rigatti

Research output: Contribution to journalArticle

Abstract

This study was designed to establish the tissutal, cellular and intracellular effects induced by transrectal prostatic hyperthermia for benign prostatic hyperplasia. Fifty-five patients with a prostatic nodule suspicious for carcinoma were submitted to a transperineal ultrasound-guided prostatic biopsy. After the histological diagnosis of benign prostatic hyperplasia these patients were submitted to ten, sixty-minute long sessions of transrectal prostatic hyperthermia with a calculated intraprostatic temperature of 42 ± 0.5%C. The same patients were submitted to a control prostatic biopsy at one-month follow-up and specimens were studied under the light and electron microscope. Morphometric analysis demonstrated a significant increase in capillary-like vessels which presented with a tortuous shape, segmented swelling and thin walls. No signs of cellular damage were noted. Cell membranes and junctions were well preserved. Transrectal prostatic hyperthermia does not cause irreversible cell damage: the capillary growth observed could increase the distribution of drugs to the gland.

Translated title of the contributionHistological and ultrastructural changes after transrectal hyperthermia for benign prostate hyperplasia
Original languageItalian
Pages (from-to)323-324
Number of pages2
JournalActa Urologica Italica
Volume6
Issue numberSUPPL. 6
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Urology

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  • Cite this

    Montorsi, F., Colombo, R., Guazzoni, G., Galli, L., Di Girolamo, V., Trabucchi, E., Bulfamante, G., Bellinzoni, P., & Rigatti, P. (1992). MODIFICAZIONI ISTOLOGICHE ED ULTRASTRUTTURALI POST IPERTERMIA TRANSRETTALE NELLA IPERPLASIA PROSTATICA BENIGNA. Acta Urologica Italica, 6(SUPPL. 6), 323-324.