Histological assessment of new bone formation with biomimetic scaffold in the presence of bone loss in trauma surgery

G Antonini, M D M Lombardo, R Giorgino, L Brambilla, A Di Giancamillo, S C Modina, M Domenicucci, L Mangiavini

Research output: Contribution to journalArticlepeer-review

Abstract

Open reduction and internal fixation (ORIF) surgery may require the use of bone grafts (usually allogeneic). In the context of traumatology surgeries, the use of autologous grafts is almost never used and allogeneic grafts are not always available. In recent years, bone substitutes have been introduced in clinical practice to overcome these limitations. The purpose of this paper is to report two cases in which the use of a bone substitute was used to overcome the bone loss during surgeries of ORIF. Two patients, one with a tibial plateau fracture (Schatzker 6) and one with a proximal humerus fracture (Neer 4), underwent ORIF surgery. In both cases, due to a loss of bone stock, a synthetic bone substitute (OrthOss®) was used. One year after surgery, the complete osseointegration of the synthetic bone substitute was seen, both radiologically and histologically. This bone substitute may represent a safe and effective alternative to autologous bone grafts, avoiding adverse events related to donor-site morbidity.

Original languageEnglish
Pages (from-to)303-307. Congress of the Italian Orthopaedic Research Society
Number of pages5
JournalJournal of Biological Regulators and Homeostatic Agents
Volume34
Issue number4 Suppl. 3
Publication statusPublished - Dec 3 2020

Fingerprint Dive into the research topics of 'Histological assessment of new bone formation with biomimetic scaffold in the presence of bone loss in trauma surgery'. Together they form a unique fingerprint.

Cite this