Histological changes and histamine release induced by dactimicin in isolated perfused rat kidney

L. Giovannini, A. A E Bertelli, M. R. Romano, M. G. Alessandri, M. Mian, R. Palla, G. Paternoster, A. Bertelli

Research output: Contribution to journalArticlepeer-review


The nephrotoxicity of aminoglycosides has been the object of numerous works of research showing that different molecules belonging to the same family of antibiotics can exert their toxic action in different ways. The aim of the present research was to evaluate the nephrotoxicity of dactimicin (DTC), a recently synthesized aminoglycoside antibiotic, as compared to gentamicin (GTM), amikacin (AMK) and fortimicin (FTM). The experimental model used was the isolated perfused rat kidney, and the parameters evaluated were histamine release and histological findings. The results showed that GTM was able to induce a significantly higher release of histamine than AMK, FTM, or DTC. AMK provoked a higher level of histamine release than FTM or DTC, although the differences between the three were not significant. Histological preparations obtained with GTM revealed large-scale lesions, which however were less detectable with AMK, and much less with DTC.

Original languageEnglish
Pages (from-to)741-745
Number of pages5
JournalDrugs under Experimental and Clinical Research
Issue number12
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Drug Discovery
  • Pharmacology


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