Histological diagnosis in myelodysplastic syndromes

G. Lambertenghi-Deliliers, C. Annaloro

Research output: Contribution to journalArticlepeer-review


Although the criteria proposed by the FAB Cooperative Group on the basis of bone marrow (BM) smears have still a clinical and prognostic relevance in myelodysplastic syndromes (MDS), the routine application of BM biopsy in these disorders have provided further morphological and prognostic informations. Distortion of marrow topography, true decrease of cellularity, increase of reticular network and presence of collagen fibrosis are the more frequent histologic features which explain the scarcity of marrow spicules in aspirates. A discrepancy between histologic and cytologic blast counts was observed in several patients; therefore, trephine biopsy appears the most accurate technique to quantify in MDS the excess of immature precursors and blasts which also appear abnormally aggregated in the central marrow. In addition, dysmegakaryocytopoiesis, iron laden macrophages, plasmacells and lymphoid infiltrates might be better identified in histologic sections. BM biopsies have demonstrated that the term MDS covers a heterogeneous population of patients, so that various hematological entities must be considered for differential diagnosis.

Original languageEnglish
Pages (from-to)109-119
Number of pages11
JournalHematology Reviews and Communications
Issue number2-3
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Hematology


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